AKA48807.1 protein (uncultured archaeon) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

Experiments

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[Homology]

Score

AKA48807.1

NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)

Predicted Functional Partners:

AKA48797.1

0.999

AKA48798.1

0.999

AKA48799.1

0.999

AKA48800.1

0.999

AKA48801.1

0.999

AKA48802.1

0.999

AKA48804.1

0.999

AKA48805.1

0.999

AKA48806.1

0.999

AKA48803.1

0.998

Your Current Organism:

uncultured archaeon

NCBI taxonomy Id: 115547
Other names: u. archaeon, uncultured Archaea archaeon, uncultured archaeoote

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKA48797.1	AKA48798.1	IX51_06410	IX51_06415	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48799.1	IX51_06410	IX51_06420	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48800.1	IX51_06410	IX51_06425	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to quinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48801.1	IX51_06410	IX51_06430	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48802.1	IX51_06410	IX51_06440	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.994
AKA48797.1	AKA48803.1	IX51_06410	IX51_06445	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.992
AKA48797.1	AKA48804.1	IX51_06410	IX51_06450	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48805.1	IX51_06410	IX51_06455	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48806.1	IX51_06410	IX51_06460	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48797.1	AKA48807.1	IX51_06410	IX51_06465	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48797.1	IX51_06415	IX51_06410	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48799.1	IX51_06415	IX51_06420	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48800.1	IX51_06415	IX51_06425	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to quinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48801.1	IX51_06415	IX51_06430	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48802.1	IX51_06415	IX51_06440	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AKA48798.1	AKA48803.1	IX51_06415	IX51_06445	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Catalyzes the transfer of electrons from NADH to ubiquinone; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.996
AKA48798.1	AKA48804.1	IX51_06415	IX51_06450	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48805.1	IX51_06415	IX51_06455	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48806.1	IX51_06415	IX51_06460	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999
AKA48798.1	AKA48807.1	IX51_06415	IX51_06465	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.999

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Network Stats

number of nodes:

11

number of edges:

19

average node degree:

3.45

avg. local clustering coefficient:

0.852

expected number of edges:

13

PPI enrichment p-value:

0.0832

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035601

Protein deacylation

2 of 22

2.23

1.18

0.0155

GO:0006357

Regulation of transcription by RNA polymerase II

5 of 470

1.3

1.09

0.0030

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004407

Histone deacetylase activity

2 of 9

2.62

1.12

0.0213

GO:0000977

RNA polymerase II transcription regulatory region sequence-specific DNA binding

3 of 95

1.77

1.01

0.0213

GO:0000981

DNA-binding transcription factor activity, RNA polymerase II-specific

3 of 233

1.38

0.8

0.0315

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9511

Mixed, incl. Homeobox, and CCAAT-binding factor complex

3 of 27

2.31

2.01

0.00071

CL:2967

Rpd3S/Clr6-CII complex, and Sds3-like

2 of 6

2.79

1.66

0.0034

CL:9514

Mixed, incl. Homeobox, and Senescence-Associated Secretory Phenotype (SASP)

2 of 17

2.34

1.22

0.0140

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04213

Longevity regulating pathway - multiple species

2 of 11

2.53

1.67

0.0030

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00850

Histone deacetylase domain

2 of 4

2.97

1.62

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003084

Histone deacetylase

2 of 2

3.27

1.59

0.0045

IPR000286

Histone deacetylase family

2 of 3

3.09

1.59

0.0045

IPR037138

Histone deacetylase domain superfamily

2 of 4

2.97

1.58

0.0045

IPR023801

Histone deacetylase domain

2 of 4

2.97

1.58

0.0045

IPR023696

Ureohydrolase domain superfamily

2 of 10

2.57

1.34

0.0098

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