node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KHJ49904.1 | KHJ51130.1 | PZ78_16140 | PZ78_10625 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.932 |
KHJ49904.1 | thyA | PZ78_16140 | PZ78_16145 | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
KHJ51130.1 | KHJ49904.1 | PZ78_10625 | PZ78_16140 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.932 |
KHJ51130.1 | KHJ51131.1 | PZ78_10625 | PZ78_10630 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.906 |
KHJ51130.1 | KHJ51132.1 | PZ78_10625 | PZ78_10635 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Colicin V production protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.849 |
KHJ51130.1 | accD | PZ78_10625 | PZ78_10620 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | acetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.913 |
KHJ51130.1 | folP | PZ78_10625 | PZ78_13215 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.995 |
KHJ51130.1 | guaA | PZ78_10625 | PZ78_16845 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.719 |
KHJ51130.1 | purF | PZ78_10625 | PZ78_10640 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.797 |
KHJ51130.1 | thyA | PZ78_10625 | PZ78_16145 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.865 |
KHJ51130.1 | trpA-2 | PZ78_10625 | PZ78_10615 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.777 |
KHJ51130.1 | truA | PZ78_10625 | PZ78_10600 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Pseudouridine synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.726 |
KHJ51131.1 | KHJ51130.1 | PZ78_10630 | PZ78_10625 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.906 |
KHJ51131.1 | KHJ51132.1 | PZ78_10630 | PZ78_10635 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Colicin V production protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.858 |
KHJ51131.1 | accD | PZ78_10630 | PZ78_10620 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | acetyl-CoA carboxyl transferase; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.842 |
KHJ51131.1 | purF | PZ78_10630 | PZ78_10640 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.768 |
KHJ51131.1 | trpA-2 | PZ78_10630 | PZ78_10615 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.561 |
KHJ51131.1 | truA | PZ78_10630 | PZ78_10600 | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Pseudouridine synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.420 |
KHJ51132.1 | KHJ51130.1 | PZ78_10635 | PZ78_10625 | Colicin V production protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.849 |
KHJ51132.1 | KHJ51131.1 | PZ78_10635 | PZ78_10630 | Colicin V production protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | acetyl-CoA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.858 |