node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DBT_0160 | DBT_0895 | DBT_0160 | DBT_0895 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Inosine monophosphate cyclohydrolase. | 0.932 |
DBT_0160 | DBT_1175 | DBT_0160 | DBT_1175 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.932 |
DBT_0160 | DBT_1408 | DBT_0160 | DBT_1408 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylglycinamide formyltransferase. | 0.958 |
DBT_0160 | cysS-2 | DBT_0160 | DBT_1713 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Cysteinyl-tRNA synthetase. | 0.412 |
DBT_0160 | folD | DBT_0160 | DBT_0886 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.851 |
DBT_0160 | glyA | DBT_0160 | DBT_0832 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.855 |
DBT_0160 | purA | DBT_0160 | DBT_0535 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.991 |
DBT_0160 | purE | DBT_0160 | DBT_1799 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.999 |
DBT_0160 | purF | DBT_0160 | DBT_0102 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.948 |
DBT_0833 | DBT_1408 | DBT_0833 | DBT_1408 | Ribose 5-phosphate isomerase B. | Phosphoribosylglycinamide formyltransferase. | 0.580 |
DBT_0833 | folD | DBT_0833 | DBT_0886 | Ribose 5-phosphate isomerase B. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.648 |
DBT_0833 | glyA | DBT_0833 | DBT_0832 | Ribose 5-phosphate isomerase B. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.985 |
DBT_0895 | DBT_0160 | DBT_0895 | DBT_0160 | Inosine monophosphate cyclohydrolase. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.932 |
DBT_0895 | DBT_1175 | DBT_0895 | DBT_1175 | Inosine monophosphate cyclohydrolase. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.989 |
DBT_0895 | DBT_1408 | DBT_0895 | DBT_1408 | Inosine monophosphate cyclohydrolase. | Phosphoribosylglycinamide formyltransferase. | 0.897 |
DBT_0895 | folD | DBT_0895 | DBT_0886 | Inosine monophosphate cyclohydrolase. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.787 |
DBT_0895 | glyA | DBT_0895 | DBT_0832 | Inosine monophosphate cyclohydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
DBT_0895 | purA | DBT_0895 | DBT_0535 | Inosine monophosphate cyclohydrolase. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.823 |
DBT_0895 | purE | DBT_0895 | DBT_1799 | Inosine monophosphate cyclohydrolase. | Phosphoribosylamine--glycine ligase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR); Belongs to the GARS family. | 0.999 |
DBT_0895 | purF | DBT_0895 | DBT_0102 | Inosine monophosphate cyclohydrolase. | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.960 |