DBT_1656 protein (Dissulfuribacter thermophilus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

DBT_1656

Uncharacterized protein. (115 aa)

Predicted Functional Partners:

DBT_1378

0.548

DBT_1186

0.540

DBT_2227

0.525

DBT_0463

0.493

DBT_0403

0.479

DBT_1476

0.437

Your Current Organism:

Dissulfuribacter thermophilus

NCBI taxonomy Id: 1156395
Other names: D. thermophilus, DSM 25762, Dissulfuribacter thermophilus Slobodkin et al. 2013, VKM B-2760, delta proteobacterium S69, strain S69

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
DBT_0403	DBT_1656	Hypothetical protein.	Uncharacterized protein.	0.479
DBT_0403	DBT_2227	Hypothetical protein.	Putative regulatory protein, FmdB family.	0.530
DBT_0463	DBT_1656	Hypothetical protein.	Uncharacterized protein.	0.493
DBT_1186	DBT_1656	Hypothetical protein.	Uncharacterized protein.	0.540
DBT_1186	DBT_2227	Hypothetical protein.	Putative regulatory protein, FmdB family.	0.503
DBT_1378	DBT_1656	Hypothetical protein.	Uncharacterized protein.	0.548
DBT_1378	DBT_2227	Hypothetical protein.	Putative regulatory protein, FmdB family.	0.460
DBT_1476	DBT_1656	Hypothetical protein.	Uncharacterized protein.	0.437
DBT_1476	DBT_2227	Hypothetical protein.	Putative regulatory protein, FmdB family.	0.419
DBT_1656	DBT_0403	Uncharacterized protein.	Hypothetical protein.	0.479
DBT_1656	DBT_0463	Uncharacterized protein.	Hypothetical protein.	0.493
DBT_1656	DBT_1186	Uncharacterized protein.	Hypothetical protein.	0.540
DBT_1656	DBT_1378	Uncharacterized protein.	Hypothetical protein.	0.548
DBT_1656	DBT_1476	Uncharacterized protein.	Hypothetical protein.	0.437
DBT_1656	DBT_2227	Uncharacterized protein.	Putative regulatory protein, FmdB family.	0.525
DBT_2227	DBT_0403	Putative regulatory protein, FmdB family.	Hypothetical protein.	0.530
DBT_2227	DBT_1186	Putative regulatory protein, FmdB family.	Hypothetical protein.	0.503
DBT_2227	DBT_1378	Putative regulatory protein, FmdB family.	Hypothetical protein.	0.460
DBT_2227	DBT_1476	Putative regulatory protein, FmdB family.	Hypothetical protein.	0.419
DBT_2227	DBT_1656	Putative regulatory protein, FmdB family.	Uncharacterized protein.	0.525

Network Stats

number of nodes:

11

number of edges:

26

average node degree:

4.73

avg. local clustering coefficient:

0.678

expected number of edges:

11

PPI enrichment p-value:

5.51e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006508

Proteolysis

5 of 171

1.25

0.85

0.0073

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008658

Penicillin binding

5 of 7

2.63

4.47

2.90e-09

GO:0004180

Carboxypeptidase activity

4 of 10

2.38

3.21

5.78e-07

GO:0008955

Peptidoglycan glycosyltransferase activity

2 of 4

2.48

1.38

0.0029

GO:0008233

Peptidase activity

5 of 144

1.32

1.3

0.00021

GO:0004185

Serine-type carboxypeptidase activity

2 of 6

2.3

1.24

0.0050

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1006

Penicillin binding

3 of 5

2.56

2.08

0.00014

CL:974

Cell shape, and Penicillin binding

4 of 21

2.06

2.07

7.26e-05

CL:4744

Mixed, incl. Beta-lactamase/transpeptidase-like, and Glycoside hydrolase, family 3, N-terminal

3 of 28

1.81

1.18

0.0042

CL:4779

Beta-lactamase, and Serine-type exopeptidase activity

2 of 6

2.3

1.0

0.0142

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

9 of 41

2.12

6.26

2.85e-16

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005886

Plasma membrane

6 of 582

0.79

0.43

0.0487

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0328

Glycosyltransferase

5 of 54

1.75

2.27

4.49e-06

KW-0121

Carboxypeptidase

3 of 10

2.26

2.08

0.00010

KW-0132

Cell division

3 of 43

1.62

1.19

0.0027

KW-0131

Cell cycle

3 of 43

1.62

1.19

0.0027

KW-0378

Hydrolase

7 of 553

0.88

0.76

0.00052

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

5 of 7

2.63

4.5

2.55e-09

PF00912

Transglycosylase

2 of 2

2.78

1.24

0.0056

PF00144

Beta-lactamase

2 of 9

2.13

0.79

0.0341

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR012338

Beta-lactamase/transpeptidase-like

9 of 24

2.35

7.34

5.78e-17

IPR001460

Penicillin-binding protein, transpeptidase

5 of 7

2.63

4.45

3.19e-09

IPR036950

Penicillin binding protein transglycosylase domain

2 of 2

2.78

1.12

0.0094

IPR001264

Glycosyl transferase, family 51

2 of 2

2.78

1.12

0.0094

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

2 of 3

2.6

1.11

0.0094

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