DBT_2145 protein (Dissulfuribacter thermophilus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

DBT_2145

Zinc ABC transporter, inner membrane permease protein ZnuB. (239 aa)

Predicted Functional Partners:

DBT_1049

0.999

DBT_0261

0.987

DBT_1475

0.981

DBT_2142

0.777

mqnD

0.773

DBT_2144

0.773

DBT_1089

0.728

DBT_1456

0.702

DBT_2146

0.682

DBT_2108

0.609

Your Current Organism:

Dissulfuribacter thermophilus

NCBI taxonomy Id: 1156395
Other names: D. thermophilus, DSM 25762, Dissulfuribacter thermophilus Slobodkin et al. 2013, VKM B-2760, delta proteobacterium S69, strain S69

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DBT_0261	DBT_1049	DBT_0261	DBT_1049	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	Zinc ABC transporter, ATP-binding protein ZnuC.	0.990
DBT_0261	DBT_1089	DBT_0261	DBT_1089	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	Ferrous iron transport protein A.	0.760
DBT_0261	DBT_1456	DBT_0261	DBT_1456	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	Vitamin B12 ABC transporter, ATPase component BtuD.	0.694
DBT_0261	DBT_1475	DBT_0261	DBT_1475	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	Dipeptide transport ATP-binding protein DppF.	0.892
DBT_0261	DBT_2108	DBT_0261	DBT_2108	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	Iron-dependent repressor IdeR/DtxR.	0.606
DBT_0261	DBT_2145	DBT_0261	DBT_2145	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	Zinc ABC transporter, inner membrane permease protein ZnuB.	0.987
DBT_1049	DBT_0261	DBT_1049	DBT_0261	Zinc ABC transporter, ATP-binding protein ZnuC.	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	0.990
DBT_1049	DBT_1089	DBT_1049	DBT_1089	Zinc ABC transporter, ATP-binding protein ZnuC.	Ferrous iron transport protein A.	0.660
DBT_1049	DBT_1456	DBT_1049	DBT_1456	Zinc ABC transporter, ATP-binding protein ZnuC.	Vitamin B12 ABC transporter, ATPase component BtuD.	0.514
DBT_1049	DBT_2108	DBT_1049	DBT_2108	Zinc ABC transporter, ATP-binding protein ZnuC.	Iron-dependent repressor IdeR/DtxR.	0.581
DBT_1049	DBT_2145	DBT_1049	DBT_2145	Zinc ABC transporter, ATP-binding protein ZnuC.	Zinc ABC transporter, inner membrane permease protein ZnuB.	0.999
DBT_1089	DBT_0261	DBT_1089	DBT_0261	Ferrous iron transport protein A.	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	0.760
DBT_1089	DBT_1049	DBT_1089	DBT_1049	Ferrous iron transport protein A.	Zinc ABC transporter, ATP-binding protein ZnuC.	0.660
DBT_1089	DBT_1475	DBT_1089	DBT_1475	Ferrous iron transport protein A.	Dipeptide transport ATP-binding protein DppF.	0.564
DBT_1089	DBT_2145	DBT_1089	DBT_2145	Ferrous iron transport protein A.	Zinc ABC transporter, inner membrane permease protein ZnuB.	0.728
DBT_1456	DBT_0261	DBT_1456	DBT_0261	Vitamin B12 ABC transporter, ATPase component BtuD.	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	0.694
DBT_1456	DBT_1049	DBT_1456	DBT_1049	Vitamin B12 ABC transporter, ATPase component BtuD.	Zinc ABC transporter, ATP-binding protein ZnuC.	0.514
DBT_1456	DBT_1475	DBT_1456	DBT_1475	Vitamin B12 ABC transporter, ATPase component BtuD.	Dipeptide transport ATP-binding protein DppF.	0.613
DBT_1456	DBT_2145	DBT_1456	DBT_2145	Vitamin B12 ABC transporter, ATPase component BtuD.	Zinc ABC transporter, inner membrane permease protein ZnuB.	0.702
DBT_1475	DBT_0261	DBT_1475	DBT_0261	Dipeptide transport ATP-binding protein DppF.	Zinc ABC transporter, periplasmic-binding protein ZnuA; Belongs to the bacterial solute-binding protein 9 family.	0.892

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0140647

P450-containing electron transport chain

2 of 2

2.93

0.87

0.0273

GO:0006631

Fatty acid metabolic process

4 of 135

1.4

0.72

0.0273

GO:0006633

Fatty acid biosynthetic process

3 of 55

1.66

0.69

0.0439

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

3 of 24

2.02

1.17

0.0056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4546

Mixed, incl. Valine, leucine and isoleucine degradation, and Fatty acid metabolic process

6 of 118

1.63

2.14

3.72e-06

CL:4547

Mixed, incl. Valine, leucine and isoleucine degradation, and TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

5 of 109

1.59

1.88

1.88e-05

CL:4738

Mixed, incl. Thioesterase domain, and Quinone oxidoreductase/zeta-crystallin, conserved site

2 of 5

2.53

1.3

0.0041

CL:12660

Protein import into peroxisome matrix, and acyl-CoA binding

2 of 6

2.45

1.25

0.0050

CL:4676

Mixed, incl. Biotin-binding site, and Fatty acid metabolism

2 of 8

2.32

1.15

0.0074

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

4 of 33

2.01

2.39

1.08e-05

map00780

Biotin metabolism

3 of 18

2.15

1.99

0.00013

map01212

Fatty acid metabolism

4 of 127

1.42

1.29

0.00060

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2395516

Electron transport from NADPH to Ferredoxin

2 of 3

2.75

1.06

0.0119

MAP-9033241

Peroxisomal protein import

4 of 188

1.25

0.69

0.0244

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