STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuA-2Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (386 aa)    
Predicted Functional Partners:
ydbK
Unannotated protein.
  
 
 0.974
leuD
Unannotated protein; Belongs to the LeuD family.
 
 
 0.956
IIL
Unannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family.
 
 0.943
ilvE
Unannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
 0.940
ilvD
Unannotated protein; Belongs to the IlvD/Edd family.
 
 
 0.926
pycA
Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
  
 
 0.915
leuB
Unannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
 0.894
ilvH
Unannotated protein.
  
 
 0.882
MFUM_700096
Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family.
  
  
 
0.875
leuA
Unannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
  
 
0.871
Your Current Organism:
Methylacidiphilum fumariolicum
NCBI taxonomy Id: 1156937
Other names: M. fumariolicum SolV, Methylacidiphilum fumariolicum SolV, Methylacidiphilum fumariolicum str. SolV, Methylacidiphilum fumariolicum strain SolV
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.