STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvNAcetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)    
Predicted Functional Partners:
ilvA
Threonine dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.999
ilvB1
Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.999
ilvB
Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
BBG46_18260
PE-PGRS family protein; Incomplete; partial on complete genome; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.998
ilvG
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.996
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
 
 
 0.994
APU26431.1
2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.993
APU27950.1
2-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
  0.991
mez
NAD-dependent malic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.973
Your Current Organism:
Mycobacterium tuberculosis variant caprae
NCBI taxonomy Id: 115862
Other names: ATCC BAA-824, CIP 105776, M. tuberculosis variant caprae, Mycobacterium bovis subsp. caprae, Mycobacterium caprae, Mycobacterium tuberculosis subsp. caprae, strain gM-1, strain spc-1
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