UV8b_8139 protein (Ustilaginoidea virens) - STRING interaction network

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

UV8b_8139

Uncharacterized protein; Belongs to the complex I LYR family. (113 aa)

Predicted Functional Partners:

UV8b_2957

0.964

UV8b_599

0.939

UV8b_6052

0.932

UV8b_5463

0.826

UV8b_7493

0.802

UV8b_4878

0.802

UV8b_1873

0.799

UV8b_4504

0.748

UV8b_7529

0.569

UV8b_769

0.508

Your Current Organism:

Ustilaginoidea virens

NCBI taxonomy Id: 1159556
Other names: Claviceps virens, MAFF 240994, MAFF 240995, TNS:F-18423, U. virens, Villosiclava virens, Villosiclava virens (Y. Sakurai ex Nakata) E. Tanaka & C. Tanaka 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
UV8b_1873	UV8b_2957	A0A063C4K4	A0A063C3K6	2Fe-2S iron-sulfur cluster binding domain containing protein.	Cysteine desulfurase.	0.963
UV8b_1873	UV8b_4504	A0A063C4K4	A0A063C004	2Fe-2S iron-sulfur cluster binding domain containing protein.	Small GTP-binding protein YPTI.	0.916
UV8b_1873	UV8b_4878	A0A063C4K4	A0A063BYY6	2Fe-2S iron-sulfur cluster binding domain containing protein.	Aminotransferase family protein (LolT).	0.877
UV8b_1873	UV8b_5463	A0A063C4K4	A0A063BUG2	2Fe-2S iron-sulfur cluster binding domain containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.917
UV8b_1873	UV8b_599	A0A063C4K4	A0A063CA58	2Fe-2S iron-sulfur cluster binding domain containing protein.	Mitochondrial iron uptake protein.	0.812
UV8b_1873	UV8b_6052	A0A063C4K4	A0A063BV10	2Fe-2S iron-sulfur cluster binding domain containing protein.	Iron sulfur cluster assembly protein.	0.943
UV8b_1873	UV8b_7493	A0A063C4K4	A0A063BLW7	2Fe-2S iron-sulfur cluster binding domain containing protein.	Putative NRPS-like enzyme.	0.877
UV8b_1873	UV8b_769	A0A063C4K4	A0A063CAQ0	2Fe-2S iron-sulfur cluster binding domain containing protein.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.490
UV8b_1873	UV8b_8139	A0A063C4K4	A0A063BKJ2	2Fe-2S iron-sulfur cluster binding domain containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.799
UV8b_2957	UV8b_1873	A0A063C3K6	A0A063C4K4	Cysteine desulfurase.	2Fe-2S iron-sulfur cluster binding domain containing protein.	0.963
UV8b_2957	UV8b_4878	A0A063C3K6	A0A063BYY6	Cysteine desulfurase.	Aminotransferase family protein (LolT).	0.414
UV8b_2957	UV8b_5463	A0A063C3K6	A0A063BUG2	Cysteine desulfurase.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.800
UV8b_2957	UV8b_599	A0A063C3K6	A0A063CA58	Cysteine desulfurase.	Mitochondrial iron uptake protein.	0.998
UV8b_2957	UV8b_6052	A0A063C3K6	A0A063BV10	Cysteine desulfurase.	Iron sulfur cluster assembly protein.	0.999
UV8b_2957	UV8b_769	A0A063C3K6	A0A063CAQ0	Cysteine desulfurase.	GrpE protein homolog; Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner; Belongs to the GrpE family.	0.456
UV8b_2957	UV8b_8139	A0A063C3K6	A0A063BKJ2	Cysteine desulfurase.	Uncharacterized protein; Belongs to the complex I LYR family.	0.964
UV8b_4504	UV8b_1873	A0A063C004	A0A063C4K4	Small GTP-binding protein YPTI.	2Fe-2S iron-sulfur cluster binding domain containing protein.	0.916
UV8b_4504	UV8b_7529	A0A063C004	A0A063BRE9	Small GTP-binding protein YPTI.	DNA repair protein rad32; Belongs to the MRE11/RAD32 family.	0.808
UV8b_4504	UV8b_8139	A0A063C004	A0A063BKJ2	Small GTP-binding protein YPTI.	Uncharacterized protein; Belongs to the complex I LYR family.	0.748
UV8b_4878	UV8b_1873	A0A063BYY6	A0A063C4K4	Aminotransferase family protein (LolT).	2Fe-2S iron-sulfur cluster binding domain containing protein.	0.877

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Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.921

expected number of edges:

15

PPI enrichment p-value:

9.92e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006085

acetyl-CoA biosynthetic process

4 of 8

2.23

2.36

2.51e-05

GO:0019427

acetyl-CoA biosynthetic process from acetate

2 of 3

2.35

1.28

0.0042

GO:0022900

Electron transport chain

5 of 96

1.25

1.14

0.00052

GO:0006091

Generation of precursor metabolites and energy

6 of 184

1.04

0.93

0.00054

GO:0032787

Monocarboxylic acid metabolic process

4 of 113

1.08

0.72

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030976

Thiamine pyrophosphate binding

4 of 8

2.23

2.49

1.32e-05

GO:0016208

AMP binding

2 of 3

2.35

1.15

0.0074

GO:0003987

acetate-CoA ligase activity

2 of 3

2.35

1.15

0.0074

GO:0043169

Cation binding

8 of 564

0.68

0.51

0.0037

GO:0036094

Small molecule binding

8 of 556

0.69

0.51

0.0037

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009274

Peptidoglycan-based cell wall

3 of 22

1.66

1.09

0.0055

GO:0005829

Cytosol

6 of 316

0.81

0.58

0.0065

GO:0005737

Cytoplasm

9 of 1132

0.43

0.31

0.0214

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1244

Citrate cycle (TCA cycle), and Propanoate metabolism

10 of 30

2.05

6.17

5.15e-17

CL:1245

Citrate cycle (TCA cycle)

6 of 23

1.95

3.42

1.14e-08

CL:1246

Citrate cycle (TCA cycle), and Novobiocin biosynthesis

5 of 14

2.08

3.23

1.40e-07

CL:1292

acetyl-CoA biosynthetic process

4 of 5

2.43

3.2

6.81e-07

CL:1248

Pyruvate ferredoxin/flavodoxin oxidoreductase, and Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.96

1.52e-06

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

daf00620

Pyruvate metabolism

11 of 38

1.99

6.53

6.02e-20

daf00650

Butanoate metabolism

5 of 14

2.08

3.58

1.76e-08

daf01200

Carbon metabolism

11 of 115

1.51

3.3

2.10e-15

daf00010

Glycolysis / Gluconeogenesis

7 of 46

1.71

3.24

6.14e-10

daf00020

Citrate cycle (TCA cycle)

5 of 22

1.89

3.03

8.64e-08

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005618

Cell wall

3 of 12

1.93

1.34

0.0023

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

4 of 98

1.14

0.71

0.0154

KW-0479

Metal-binding

6 of 263

0.89

0.61

0.0093

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02775

Thiamine pyrophosphate enzyme, C-terminal TPP binding domain

4 of 7

2.29

2.62

7.79e-06

PF01855

Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg

2 of 5

2.13

0.71

0.0481

PF01558

Pyruvate ferredoxin/flavodoxin oxidoreductase

2 of 5

2.13

0.71

0.0481

PF13193

AMP-binding enzyme C-terminal domain

2 of 7

1.99

0.7

0.0481

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR029061

Thiamin diphosphate-binding fold

5 of 16

2.02

2.68

2.24e-06

IPR011766

Thiamine pyrophosphate enzyme, TPP-binding

4 of 7

2.29

2.58

9.79e-06

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