node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FEN1 | UV8b_1281 | A0A063BTT3 | A0A063CBL9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | 0.796 |
FEN1 | UV8b_1383 | A0A063BTT3 | A0A063CAH8 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Exonuclease. | 0.867 |
FEN1 | UV8b_1954 | A0A063BTT3 | A0A063C7A3 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repaire protein UVS6. | 0.932 |
FEN1 | UV8b_3254 | A0A063BTT3 | A0A063C399 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Ku70 protein. | 0.709 |
FEN1 | UV8b_6081 | A0A063BTT3 | A0A063BS81 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Werner syndrome helicase. | 0.999 |
FEN1 | UV8b_7476 | A0A063BTT3 | A0A063BLZ9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | BRCT domain-containing protein. | 0.691 |
FEN1 | UV8b_7529 | A0A063BTT3 | A0A063BRE9 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | DNA repair protein rad32; Belongs to the MRE11/RAD32 family. | 0.982 |
FEN1 | UV8b_7951 | A0A063BTT3 | A0A063BRG1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.840 |
FEN1 | UV8b_7988 | A0A063BTT3 | A0A063BQ75 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. | 0.671 |
FEN1 | UV8b_979 | A0A063BTT3 | A0A063C725 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | 0.834 |
UV8b_1281 | FEN1 | A0A063CBL9 | A0A063BTT3 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.796 |
UV8b_1281 | UV8b_1383 | A0A063CBL9 | A0A063CAH8 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | Exonuclease. | 0.894 |
UV8b_1281 | UV8b_1954 | A0A063CBL9 | A0A063C7A3 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | DNA repaire protein UVS6. | 0.987 |
UV8b_1281 | UV8b_3254 | A0A063CBL9 | A0A063C399 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | Ku70 protein. | 0.932 |
UV8b_1281 | UV8b_6081 | A0A063CBL9 | A0A063BS81 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | Werner syndrome helicase. | 0.992 |
UV8b_1281 | UV8b_7476 | A0A063CBL9 | A0A063BLZ9 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | BRCT domain-containing protein. | 0.935 |
UV8b_1281 | UV8b_7529 | A0A063CBL9 | A0A063BRE9 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | DNA repair protein rad32; Belongs to the MRE11/RAD32 family. | 0.989 |
UV8b_1281 | UV8b_7951 | A0A063CBL9 | A0A063BRG1 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.889 |
UV8b_1281 | UV8b_7988 | A0A063CBL9 | A0A063BQ75 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | ATP-dependent DNA helicase II subunit 2; Single-stranded DNA-dependent ATP-dependent helicase. | 0.896 |
UV8b_1281 | UV8b_979 | A0A063CBL9 | A0A063C725 | Serine/threonine-protein kinase tel-1; Belongs to the PI3/PI4-kinase family. | Protein kinase rad3; Belongs to the PI3/PI4-kinase family. | 0.997 |