UV8b_4985 protein (Ustilaginoidea virens) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

UV8b_4985

Putative hydrolase. (140 aa)

Predicted Functional Partners:

UV8b_7562

0.912

UV8b_3346

0.795

UV8b_5068

0.778

UV8b_5287

0.743

UV8b_1454

0.721

UV8b_4440

0.667

UV8b_7797

0.660

UV8b_5534

0.642

UV8b_846

0.642

UV8b_2302

0.635

Your Current Organism:

Ustilaginoidea virens

NCBI taxonomy Id: 1159556
Other names: Claviceps virens, MAFF 240994, MAFF 240995, TNS:F-18423, U. virens, Villosiclava virens, Villosiclava virens (Y. Sakurai ex Nakata) E. Tanaka & C. Tanaka 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
UV8b_1454	UV8b_4985	A0A063C3G1	A0A063BTN7	Aldose 1-epimerase.	Putative hydrolase.	0.721
UV8b_1454	UV8b_5068	A0A063C3G1	A0A063C0R2	Aldose 1-epimerase.	Beta-galactosidase.	0.838
UV8b_1454	UV8b_5287	A0A063C3G1	A0A063BY06	Aldose 1-epimerase.	Putative beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.	0.856
UV8b_1454	UV8b_7562	A0A063C3G1	A0A063BLU2	Aldose 1-epimerase.	UDP-glucose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.	0.676
UV8b_1454	UV8b_7797	A0A063C3G1	A0A063BL92	Aldose 1-epimerase.	NAD dependent epimerase/dehydratase family protein.	0.676
UV8b_2302	UV8b_3346	A0A063C2Y6	A0A063C015	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	Sulfatase.	0.612
UV8b_2302	UV8b_4985	A0A063C2Y6	A0A063BTN7	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	Putative hydrolase.	0.635
UV8b_2302	UV8b_5287	A0A063C2Y6	A0A063BY06	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	Putative beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.	0.402
UV8b_2302	UV8b_5534	A0A063C2Y6	A0A063BWU1	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	Sulfatase domain protein.	0.626
UV8b_2302	UV8b_846	A0A063C2Y6	A0A063CDJ3	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	Cellular morphogenesis protein.	0.626
UV8b_3346	UV8b_2302	A0A063C015	A0A063C2Y6	Sulfatase.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.612
UV8b_3346	UV8b_4985	A0A063C015	A0A063BTN7	Sulfatase.	Putative hydrolase.	0.795
UV8b_3346	UV8b_5068	A0A063C015	A0A063C0R2	Sulfatase.	Beta-galactosidase.	0.801
UV8b_3346	UV8b_5534	A0A063C015	A0A063BWU1	Sulfatase.	Sulfatase domain protein.	0.680
UV8b_3346	UV8b_846	A0A063C015	A0A063CDJ3	Sulfatase.	Cellular morphogenesis protein.	0.680
UV8b_4440	UV8b_4985	A0A063C259	A0A063BTN7	Carboxylesterase family protein.	Putative hydrolase.	0.667
UV8b_4985	UV8b_1454	A0A063BTN7	A0A063C3G1	Putative hydrolase.	Aldose 1-epimerase.	0.721
UV8b_4985	UV8b_2302	A0A063BTN7	A0A063C2Y6	Putative hydrolase.	ADP-ribosylation factor; Belongs to the small GTPase superfamily. Arf family.	0.635
UV8b_4985	UV8b_3346	A0A063BTN7	A0A063C015	Putative hydrolase.	Sulfatase.	0.795
UV8b_4985	UV8b_4440	A0A063BTN7	A0A063C259	Putative hydrolase.	Carboxylesterase family protein.	0.667

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.934

expected number of edges:

10

PPI enrichment p-value:

2.27e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

8 of 26

2.45

6.9

3.60e-15

GO:0019752

Carboxylic acid metabolic process

5 of 339

1.13

0.76

0.0094

GO:0044281

Small molecule metabolic process

6 of 622

0.95

0.65

0.0094

GO:0044237

Cellular metabolic process

10 of 3101

0.47

0.33

0.0195

GO:0044238

Primary metabolic process

10 of 3357

0.44

0.29

0.0379

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

2 of 2

2.96

1.14

0.0087

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

2 of 11

2.22

0.84

0.0280

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005739

Mitochondrion

7 of 709

0.96

0.77

0.0018

GO:0005737

Cytoplasm

11 of 4006

0.4

0.3

0.0152

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:8804

Tricarboxylic acid cycle, and Biotin transport and metabolism

9 of 41

2.3

7.15

6.47e-17

CL:8807

Tricarboxylic acid cycle, and Aspartate metabolic process

7 of 24

2.43

6.19

1.44e-13

CL:8832

Tricarboxylic acid cycle

4 of 10

2.57

3.51

2.17e-07

CL:8808

Tricarboxylic acid cycle, and Aspartate metabolic process

3 of 12

2.36

2.11

0.00010

CL:8834

Fumarate reductase complex, and 3Fe-4S

2 of 5

2.57

1.28

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00020

Citrate cycle (TCA cycle)

8 of 33

2.35

6.89

8.05e-16

map01200

Carbon metabolism

8 of 121

1.78

3.9

6.28e-12

map00630

Glyoxylate and dicarboxylate metabolism

4 of 38

1.99

2.55

3.87e-06

map01210

2-Oxocarboxylic acid metabolism

3 of 28

1.99

1.97

9.86e-05

map01110

Biosynthesis of secondary metabolites

7 of 447

1.16

1.35

3.87e-06

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71403

Citric acid cycle (TCA cycle)

6 of 25

2.34

4.72

2.10e-10

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

6 of 44

2.1

3.94

2.25e-09

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

6 of 121

1.66

2.43

4.72e-07

MAP-1430728

Metabolism

9 of 984

0.92

0.95

8.68e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

2 of 3

2.79

1.2

0.0067

GOCC:0098798

Mitochondrial protein complex

3 of 139

1.3

0.63

0.0407

GOCC:0005739

Mitochondrion

5 of 526

0.94

0.58

0.0196

GOCC:0005737

Cytoplasm

10 of 2476

0.57

0.42

0.0067

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

2 of 7

2.42

1.12

0.0087

KW-0830

Ubiquinone

2 of 9

2.31

1.11

0.0087

KW-0809

Transit peptide

2 of 14

2.12

1.07

0.0096

KW-0411

Iron-sulfur

2 of 20

1.96

0.97

0.0138

KW-0456

Lyase

2 of 40

1.66

0.71

0.0407

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00549

CoA-ligase

2 of 3

2.79

1.1

0.0100

PF00285

Citrate synthase, C-terminal domain

2 of 5

2.57

1.09

0.0105

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017866

Succinyl-CoA synthetase, beta subunit, conserved site

2 of 2

2.96

0.98

0.0172

IPR016102

Succinyl-CoA synthetase-like

2 of 3

2.79

0.98

0.0172

IPR005811

ATP-citrate lyase/succinyl-CoA ligase

2 of 3

2.79

0.98

0.0172

IPR036969

Citrate synthase superfamily

2 of 5

2.57

0.97

0.0172

IPR016143

Citrate synthase-like, small alpha subdomain

2 of 5

2.57

0.97

0.0172

(more ...)

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