UV8b_3941 protein (Ustilaginoidea virens) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

UV8b_3941

Putative ER membrane protein (Wsc4). (316 aa)

Predicted Functional Partners:

UV8b_1973

0.859

UV8b_7951

0.726

UV8b_6302

0.712

UV8b_5226

0.711

UV8b_5227

0.711

UV8b_2352

0.711

UV8b_2258

0.711

UV8b_5660

0.705

UV8b_7316

0.694

UV8b_1748

0.682

Your Current Organism:

Ustilaginoidea virens

NCBI taxonomy Id: 1159556
Other names: Claviceps virens, MAFF 240994, MAFF 240995, TNS:F-18423, U. virens, Villosiclava virens, Villosiclava virens (Y. Sakurai ex Nakata) E. Tanaka & C. Tanaka 2009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
UV8b_1748	UV8b_3941	A0A063C487	A0A063BYC6	MUS38-like protein.	Putative ER membrane protein (Wsc4).	0.682
UV8b_1748	UV8b_5660	A0A063C487	A0A063BWH1	MUS38-like protein.	NPL4 family protein.	0.956
UV8b_1748	UV8b_6302	A0A063C487	A0A063BV45	MUS38-like protein.	Nuclear transport factor 2.	0.860
UV8b_1748	UV8b_7316	A0A063C487	A0A063BSS5	MUS38-like protein.	OB domain-containing protein.	0.901
UV8b_1748	UV8b_7951	A0A063C487	A0A063BRG1	MUS38-like protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.980
UV8b_1973	UV8b_3941	A0A063C4U4	A0A063BYC6	Putative Rho guanyl nucleotide exchange factor (Rom2).	Putative ER membrane protein (Wsc4).	0.859
UV8b_2258	UV8b_3941	A0A063C5A3	A0A063BYC6	Uncharacterized protein.	Putative ER membrane protein (Wsc4).	0.711
UV8b_2352	UV8b_3941	A0A063C332	A0A063BYC6	dUTP pyrophosphatase.	Putative ER membrane protein (Wsc4).	0.711
UV8b_3941	UV8b_1748	A0A063BYC6	A0A063C487	Putative ER membrane protein (Wsc4).	MUS38-like protein.	0.682
UV8b_3941	UV8b_1973	A0A063BYC6	A0A063C4U4	Putative ER membrane protein (Wsc4).	Putative Rho guanyl nucleotide exchange factor (Rom2).	0.859
UV8b_3941	UV8b_2258	A0A063BYC6	A0A063C5A3	Putative ER membrane protein (Wsc4).	Uncharacterized protein.	0.711
UV8b_3941	UV8b_2352	A0A063BYC6	A0A063C332	Putative ER membrane protein (Wsc4).	dUTP pyrophosphatase.	0.711
UV8b_3941	UV8b_5226	A0A063BYC6	A0A063BXE5	Putative ER membrane protein (Wsc4).	Uncharacterized protein.	0.711
UV8b_3941	UV8b_5227	A0A063BYC6	A0A063BXT2	Putative ER membrane protein (Wsc4).	Uncharacterized protein.	0.711
UV8b_3941	UV8b_5660	A0A063BYC6	A0A063BWH1	Putative ER membrane protein (Wsc4).	NPL4 family protein.	0.705
UV8b_3941	UV8b_6302	A0A063BYC6	A0A063BV45	Putative ER membrane protein (Wsc4).	Nuclear transport factor 2.	0.712
UV8b_3941	UV8b_7316	A0A063BYC6	A0A063BSS5	Putative ER membrane protein (Wsc4).	OB domain-containing protein.	0.694
UV8b_3941	UV8b_7951	A0A063BYC6	A0A063BRG1	Putative ER membrane protein (Wsc4).	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.726
UV8b_5226	UV8b_3941	A0A063BXE5	A0A063BYC6	Uncharacterized protein.	Putative ER membrane protein (Wsc4).	0.711
UV8b_5227	UV8b_3941	A0A063BXT2	A0A063BYC6	Uncharacterized protein.	Putative ER membrane protein (Wsc4).	0.711

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

27

PPI enrichment p-value:

8.74e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

10 of 116

1.57

3.2

1.96e-12

GO:0010467

Gene expression

11 of 211

1.35

2.4

1.96e-12

GO:0009059

Macromolecule biosynthetic process

11 of 268

1.25

2.03

6.02e-12

GO:0044271

Cellular nitrogen compound biosynthetic process

11 of 404

1.07

1.44

3.38e-10

GO:0044238

Primary metabolic process

11 of 1331

0.55

0.48

6.74e-05

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

10 of 57

1.88

5.03

1.42e-15

GO:0019843

rRNA binding

6 of 41

1.8

2.88

8.24e-08

GO:0003676

Nucleic acid binding

7 of 522

0.76

0.54

0.0075

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

10 of 60

1.85

5.04

3.86e-16

GO:0044391

Ribosomal subunit

3 of 14

1.96

1.89

0.00014

GO:0015935

Small ribosomal subunit

2 of 6

2.15

1.39

0.0023

GO:0032991

Protein-containing complex

4 of 227

0.88

0.55

0.0189

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2421

rRNA-binding, and Structural constituent of ribosome

10 of 41

2.02

6.12

1.91e-17

CL:2419

Structural constituent of ribosome

11 of 58

1.91

5.73

2.92e-18

CL:2479

rRNA-binding, and RNA polymerase

6 of 12

2.33

4.99

4.39e-11

CL:2422

rRNA-binding, and Elongation factor G C-terminus

4 of 29

1.77

1.95

4.65e-05

CL:2481

Ribosomal protein S5 domain 2-type fold, subgroup, and Structural constituent of ribosome

2 of 6

2.15

1.08

0.0094

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

10 of 59

1.86

5.09

3.29e-16

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

9 of 47

1.91

4.87

4.06e-14

GOCC:0015935

Small ribosomal subunit

4 of 12

2.15

2.79

2.27e-06

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 10

1.93

1.03

0.0102

GOCC:0032991

Protein-containing complex

6 of 589

0.64

0.4

0.0296

GOCC:0005622

Intracellular

11 of 1652

0.46

0.39

0.00036

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

10 of 58

1.87

5.1

4.47e-16

KW-0699

rRNA-binding

6 of 38

1.83

3.17

1.46e-08

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