STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ligATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. (599 aa)    
Predicted Functional Partners:
fen
Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
 
 0.937
pcn-3
DNA polymerase sliding clamp subunit; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
 
 0.913
pcn
Proliferating cell nuclear antigen, PCNA; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 0.902
pcn-2
DNA polymerase sliding clamp B2; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. Belongs to the PCNA family.
  
 0.902
AFH42782.1
Metallophosphoesterase Mre11-like protein.
 
 0.835
AFH43045.1
Exonuclease of the beta-lactamase fold involved in RNA processing-like protein.
 
 0.835
rfcL
Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
   
 0.832
AFH42863.1
DNA polymerase I.
 
 0.804
AFH43227.1
DNA polymerase B region.
 
 0.801
AFH42783.1
Rad50 zinc hook domain protein.
  
 0.792
Your Current Organism:
Fervidicoccus fontis
NCBI taxonomy Id: 1163730
Other names: Desulfurococcales archaeon Kam940, F. fontis Kam940, Fervidicoccus fontis DSM 19380, Fervidicoccus fontis Kam940, Fervidicoccus fontis str. Kam940, Fervidicoccus fontis strain Kam940
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