node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFE91747.1 | SFF08712.1 | SAMN05216566_10166 | SAMN05216566_102387 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.999 |
SFE91747.1 | SFF18654.1 | SAMN05216566_10166 | SAMN05216566_10486 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE. | 0.902 |
SFE91747.1 | SFF29155.1 | SAMN05216566_10166 | SAMN05216566_10729 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thiol-disulfide isomerase or thioredoxin. | 0.902 |
SFE91747.1 | SFF32957.1 | SAMN05216566_10166 | SAMN05216566_10852 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Glutaredoxin. | 0.989 |
SFE91747.1 | SFF36215.1 | SAMN05216566_10166 | SAMN05216566_109105 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.994 |
SFE91747.1 | SFF38070.1 | SAMN05216566_10166 | SAMN05216566_11035 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.823 |
SFE91747.1 | SFF54752.1 | SAMN05216566_10166 | SAMN05216566_12554 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.823 |
SFE91747.1 | dut | SAMN05216566_10166 | SAMN05216566_11023 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.948 |
SFE91747.1 | polA | SAMN05216566_10166 | SAMN05216566_110127 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.822 |
SFE91747.1 | thyA | SAMN05216566_10166 | SAMN05216566_105175 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.897 |
SFF08712.1 | SFE91747.1 | SAMN05216566_102387 | SAMN05216566_10166 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.999 |
SFF08712.1 | SFF18654.1 | SAMN05216566_102387 | SAMN05216566_10486 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE. | 0.842 |
SFF08712.1 | SFF29155.1 | SAMN05216566_102387 | SAMN05216566_10729 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Thiol-disulfide isomerase or thioredoxin. | 0.839 |
SFF08712.1 | SFF38070.1 | SAMN05216566_102387 | SAMN05216566_11035 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.764 |
SFF08712.1 | SFF54752.1 | SAMN05216566_102387 | SAMN05216566_12554 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA polymerase-3 subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.726 |
SFF08712.1 | dut | SAMN05216566_102387 | SAMN05216566_11023 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | dUTP pyrophosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.764 |
SFF08712.1 | polA | SAMN05216566_102387 | SAMN05216566_110127 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.642 |
SFF08712.1 | thyA | SAMN05216566_102387 | SAMN05216566_105175 | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.711 |
SFF18654.1 | SFE91747.1 | SAMN05216566_10486 | SAMN05216566_10166 | Cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.902 |
SFF18654.1 | SFF08712.1 | SAMN05216566_10486 | SAMN05216566_102387 | Cytochrome c biogenesis protein CcmG, thiol:disulfide interchange protein DsbE. | Putative transcriptional regulator; Belongs to the UPF0301 (AlgH) family. | 0.842 |