STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lexASOS regulatory protein LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (207 aa)    
Predicted Functional Partners:
recA
Protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 
 0.978
UWK_01837
nucleotidyltransferase/DNA polymerase involved in DNA repair; PFAM: Domain of unknown function (DUF4113); impB/mucB/samB family C-terminal; impB/mucB/samB family.
 
 
 0.966
UWK_01836
PFAM: Protein of unknown function DUF72.
 
     0.845
UWK_01838
PFAM: Bacterial DNA polymerase III alpha subunit; PHP domain; OB-fold nucleic acid binding domain; TIGRFAM: DNA-directed DNA polymerase III (polc); Belongs to the DNA polymerase type-C family.
 
   
 0.793
dinB
nucleotidyltransferase/DNA polymerase involved in DNA repair; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.
 
 
 0.793
UWK_02400
DNA replication and repair protein RecN; May be involved in recombinational repair of damaged DNA.
   
  
 0.767
UWK_01716
Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid.
    
 0.631
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.483
UWK_01834
PFAM: Protein of unknown function (DUF1566).
       0.474
recO
DNA replication and repair protein RecO; Involved in DNA repair and RecF pathway recombination.
 
   
 0.473
Your Current Organism:
Desulfocapsa sulfexigens
NCBI taxonomy Id: 1167006
Other names: D. sulfexigens DSM 10523, Desulfocapsa sulfexigens DSM 10523, Desulfocapsa sulfexigens SB164P1, Desulfocapsa sulfexigens str. DSM 10523, Desulfocapsa sulfexigens strain DSM 10523
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