STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
UWK_02376PFAM: Methylene-tetrahydrofolate reductase C terminal; Methylenetetrahydrofolate reductase. (508 aa)    
Predicted Functional Partners:
folD
5,10-methylene-tetrahydrofolate dehydrogenase/methenyl tetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
    
 0.994
UWK_01140
PFAM: Pterin binding enzyme.
 
  
 0.988
UWK_02780
Cobalamin-dependent methionine synthase I; PFAM: Homocysteine S-methyltransferase.
  
 
 0.960
UWK_02779
Methionine synthase I; PFAM: Pterin binding enzyme; Vitamin B12 dependent methionine synthase, activation domain; B12 binding domain; TIGRFAM: 5-methyltetrahydrofolate--homocysteine methyltransferase; contains cobalamin-binding domain.
  
 
 0.955
UWK_03163
PFAM: Methylenetetrahydrofolate reductase; CO dehydrogenase/acetyl-CoA synthase delta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase, delta subunit.
 
  
0.941
UWK_00894
Flagellin/flagellar hook associated protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
      
 0.934
hypA
Zn finger protein HypA/HybF (possibly regulating hydrogenase expression); Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
      
 0.933
glyA
Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.933
UWK_03107
Flagellin/flagellar hook associated protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.
      
 0.932
UWK_01162
Hydrogenase maturation protein, carbamoyl dehydratase HypE; PFAM: AIR synthase related protein, N-terminal domain; AIR synthase related protein, C-terminal domain; TIGRFAM: hydrogenase expression/formation protein HypE.
     
 0.931
Your Current Organism:
Desulfocapsa sulfexigens
NCBI taxonomy Id: 1167006
Other names: D. sulfexigens DSM 10523, Desulfocapsa sulfexigens DSM 10523, Desulfocapsa sulfexigens SB164P1, Desulfocapsa sulfexigens str. DSM 10523, Desulfocapsa sulfexigens strain DSM 10523
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