STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
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[Homology]
Score
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (559 aa)    
Predicted Functional Partners:
leuC
Homoaconitate hydratase family protein/3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 
 0.979
UWK_02827
PFAM: Aconitase C-terminal domain; TIGRFAM: 3-isopropylmalate dehydratase, small subunit; Belongs to the LeuD family.
 
 
 0.978
UWK_01376
PFAM: Aminotransferase class IV; TIGRFAM: branched-chain amino acid aminotransferase, group II.
  
 0.968
ilvD
PFAM: Dehydratase family; TIGRFAM: dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 
 0.967
UWK_02593
PFAM: Small subunit of acetolactate synthase; ACT domain; TIGRFAM: acetolactate synthase, small subunit.
 
 
 0.946
UWK_03058
Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: Domain of unknown function; 4Fe-4S dicluster domain; Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric.
  
 
 0.944
UWK_03471
Pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; PFAM: Domain of unknown function; Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg; Pyruvate ferredoxin/flavodoxin oxidoreductase; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; TIGRFAM: pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric.
  
 
 0.944
UWK_01179
Alcohol dehydrogenase, class IV; PFAM: Aldehyde dehydrogenase family; Iron-containing alcohol dehydrogenase.
  
 0.937
UWK_00187
Biotin carboxylase; PFAM: Carbamoyl-phosphate synthase L chain, ATP binding domain; Biotin carboxylase C-terminal domain; Carbamoyl-phosphate synthase L chain, N-terminal domain.
  
 
 0.933
acsA
Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
  
 
 0.914
Your Current Organism:
Desulfocapsa sulfexigens
NCBI taxonomy Id: 1167006
Other names: D. sulfexigens DSM 10523, Desulfocapsa sulfexigens DSM 10523, Desulfocapsa sulfexigens SB164P1, Desulfocapsa sulfexigens str. DSM 10523, Desulfocapsa sulfexigens strain DSM 10523
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