STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
W97_04798Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (728 aa)    
Predicted Functional Partners:
W97_03637
Autophagy-related protein 3.
  
 
 0.999
W97_07307
Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.
    
 0.999
W97_00921
Autophagy-related protein.
  
 0.998
W97_01924
Fungal_trans domain-containing protein.
   
 0.983
W97_06781
Uncharacterized protein.
  
 0.965
W97_04083
Lipase_3 domain-containing protein.
   
 
 0.964
W97_05913
Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.
    
 0.931
W97_04997
Autophagy_act_C domain-containing protein.
   
 0.924
W97_08769
NEDD8-conjugating enzyme UBC12; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.890
W97_00224
Autophagy-like protein 18.
    
 0.879
Your Current Organism:
Coniosporium apollinis
NCBI taxonomy Id: 1168221
Other names: C. apollinis CBS 100218, Coniosporium apollinis CBS 100218, Coniosporium apollinis CBS 352.97
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