W97_06850 protein (Coniosporium apollinis) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

W97_06850

Uncharacterized protein; Belongs to the complex I LYR family. (110 aa)

Predicted Functional Partners:

W97_03153

0.999

W97_07105

0.998

W97_07451

0.998

W97_02921

0.978

W97_04655

0.951

W97_00846

0.912

W97_04454

0.912

W97_06849

0.894

W97_04449

0.884

W97_06205

0.884

Your Current Organism:

Coniosporium apollinis

NCBI taxonomy Id: 1168221
Other names: C. apollinis CBS 100218, Coniosporium apollinis CBS 100218, Coniosporium apollinis CBS 352.97

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W97_00846	W97_04449	R7YJ47	R7YTF3	GTP-binding protein ypt1.	Lipase_GDSL domain-containing protein.	0.562
W97_00846	W97_06205	R7YJ47	R7YY68	GTP-binding protein ypt1.	Uncharacterized protein.	0.562
W97_00846	W97_06850	R7YJ47	R7Z0M2	GTP-binding protein ypt1.	Uncharacterized protein; Belongs to the complex I LYR family.	0.912
W97_02921	W97_03153	R7YPC3	R7YPS4	Aminotran_5 domain-containing protein.	Cysteine desulfurase, mitochondrial.	0.450
W97_02921	W97_04655	R7YPC3	R7YU24	Aminotran_5 domain-containing protein.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.856
W97_02921	W97_06850	R7YPC3	R7Z0M2	Aminotran_5 domain-containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.978
W97_02921	W97_07105	R7YPC3	R7Z0W7	Aminotran_5 domain-containing protein.	Iron donor protein CyaY.	0.983
W97_02921	W97_07451	R7YPC3	R7Z1N3	Aminotran_5 domain-containing protein.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.997
W97_03153	W97_02921	R7YPS4	R7YPC3	Cysteine desulfurase, mitochondrial.	Aminotran_5 domain-containing protein.	0.450
W97_03153	W97_04655	R7YPS4	R7YU24	Cysteine desulfurase, mitochondrial.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.877
W97_03153	W97_06850	R7YPS4	R7Z0M2	Cysteine desulfurase, mitochondrial.	Uncharacterized protein; Belongs to the complex I LYR family.	0.999
W97_03153	W97_07105	R7YPS4	R7Z0W7	Cysteine desulfurase, mitochondrial.	Iron donor protein CyaY.	0.999
W97_03153	W97_07451	R7YPS4	R7Z1N3	Cysteine desulfurase, mitochondrial.	Iron-sulfur cluster assembly protein; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.	0.999
W97_04449	W97_00846	R7YTF3	R7YJ47	Lipase_GDSL domain-containing protein.	GTP-binding protein ypt1.	0.562
W97_04449	W97_04454	R7YTF3	R7YTF9	Lipase_GDSL domain-containing protein.	Uncharacterized protein.	0.562
W97_04449	W97_06850	R7YTF3	R7Z0M2	Lipase_GDSL domain-containing protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.884
W97_04454	W97_04449	R7YTF9	R7YTF3	Uncharacterized protein.	Lipase_GDSL domain-containing protein.	0.562
W97_04454	W97_06205	R7YTF9	R7YY68	Uncharacterized protein.	Uncharacterized protein.	0.562
W97_04454	W97_06850	R7YTF9	R7Z0M2	Uncharacterized protein.	Uncharacterized protein; Belongs to the complex I LYR family.	0.912
W97_04655	W97_02921	R7YU24	R7YPC3	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	Aminotran_5 domain-containing protein.	0.856

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.837

expected number of edges:

13

PPI enrichment p-value:

0.00571

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048643

Positive regulation of skeletal muscle tissue development

4 of 8

2.88

3.63

2.02e-07

GO:0048743

Positive regulation of skeletal muscle fiber development

3 of 4

3.05

2.97

4.00e-06

GO:0042693

Muscle cell fate commitment

3 of 12

2.58

2.37

3.83e-05

GO:0045663

Positive regulation of myoblast differentiation

3 of 15

2.48

2.25

6.08e-05

GO:0045165

Cell fate commitment

5 of 150

1.7

2.07

1.25e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070888

E-box binding

4 of 28

2.33

2.77

4.38e-06

GO:0043425

bHLH transcription factor binding

3 of 18

2.4

2.12

0.00010

GO:0046983

Protein dimerization activity

9 of 690

1.29

1.84

5.31e-08

GO:0140297

DNA-binding transcription factor binding

5 of 288

1.42

1.44

0.00015

GO:0000978

RNA polymerase II cis-regulatory region sequence-specific DNA binding

7 of 732

1.16

1.2

6.27e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005667

Transcription regulator complex

7 of 333

1.5

2.12

5.73e-07

GO:0005634

Nucleus

11 of 5262

0.5

0.4

0.0021

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:38003577

(2023) Whole-Transcriptome RNA Sequencing Uncovers the Global Expression Changes and RNA Regulatory Networks in Duck Embryonic Myogenesis.

2 of 6

2.7

1.08

0.0112

PMID:37729680

(2023) Dietary zinc supplementation in breeding pigeons improves the carcass traits of squabs through regulating antioxidant capacity and myogenic regulatory factor expression.

2 of 3

3.0

1.08

0.0112

PMID:37170512

(2023) Current technologies, regulation, and future perspective of animal product analogs - A review.

2 of 4

2.88

1.08

0.0112

PMID:37108828

(2023) Sow-Offspring Diets Supplemented with Probiotics and Synbiotics Are Associated with Offsprings Growth Performance and Meat Quality.

2 of 5

2.78

1.08

0.0112

PMID:36697366

(2023) Genome-wide association studies demonstrate the genes associated with perimysial thickness in ducks.

2 of 4

2.88

1.08

0.0112

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22056

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and DNA-binding protein inhibitor

7 of 17

2.79

7.53

3.02e-15

CL:21810

DNA-binding transcription factor activity, RNA polymerase II-specific, and DNA-binding protein inhibitor

10 of 162

1.97

5.57

4.34e-16

CL:22058

RUNX1 regulates transcription of genes involved in differentiation of HSCs, and Runx inhibition domain

4 of 11

2.74

3.82

7.45e-08

CL:22080

DNA-binding protein inhibitor, and E-box binding

3 of 5

2.96

2.88

5.56e-06

CL:21814

Mixed, incl. Myogenesis, and Sox developmental protein N-terminal

3 of 34

2.12

1.64

0.00068

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-525793

Myogenesis

7 of 37

2.46

6.11

3.01e-13

MAP-1266738

Developmental Biology

7 of 573

1.27

1.45

1.48e-05

MAP-2559585

Oncogene Induced Senescence

2 of 11

2.44

0.96

0.0172

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005634

Nucleus

9 of 2704

0.7

0.51

0.0050

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12232

Myogenic determination factor 5

2 of 2

3.18

1.3

0.0046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036638

Helix-loop-helix DNA-binding domain superfamily

6 of 85

2.03

3.29

6.24e-08

IPR011598

Myc-type, basic helix-loop-helix (bHLH) domain

6 of 85

2.03

3.29

6.24e-08

IPR039704

Myogenic factor

3 of 3

3.18

2.79

8.71e-06

IPR002546

Myogenic muscle-specific protein, N-terminal

3 of 3

3.18

2.79

8.71e-06

IPR022032

Myogenic determination factor 5

2 of 2

3.18

1.41

0.0029

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00353

Helix loop helix domain

6 of 89

2.01

3.55

9.76e-09

SM00520

Basic domain in HLH proteins of MYOD family

3 of 3

3.18

3.2

1.57e-06

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