W97_07836 protein (Coniosporium apollinis) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

W97_07836

Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. (509 aa)

Predicted Functional Partners:

W97_02175

0.643

W97_04934

0.581

W97_00919

0.483

W97_05990

0.483

W97_06720

0.465

W97_04364

0.448

W97_04769

0.440

W97_08166

0.440

W97_08815

0.438

W97_02355

0.437

Your Current Organism:

Coniosporium apollinis

NCBI taxonomy Id: 1168221
Other names: C. apollinis CBS 100218, Coniosporium apollinis CBS 100218, Coniosporium apollinis CBS 352.97

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
W97_00919	W97_04364	R7YIJ1	R7YT88	Uncharacterized protein.	POT family proton-dependent oligopeptide transporter.	0.412
W97_00919	W97_06720	R7YIJ1	R7Z0K8	Uncharacterized protein.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.449
W97_00919	W97_07836	R7YIJ1	R7Z3A7	Uncharacterized protein.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.483
W97_02175	W97_07836	R7YMA6	R7Z3A7	Nudix hydrolase domain-containing protein.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.643
W97_02355	W97_07836	R7YMQ2	R7Z3A7	GTP cyclohydrolase I.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.437
W97_04364	W97_00919	R7YT88	R7YIJ1	POT family proton-dependent oligopeptide transporter.	Uncharacterized protein.	0.412
W97_04364	W97_05990	R7YT88	R7YY80	POT family proton-dependent oligopeptide transporter.	Aminopeptidase.	0.412
W97_04364	W97_07836	R7YT88	R7Z3A7	POT family proton-dependent oligopeptide transporter.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.448
W97_04769	W97_07836	R7YV37	R7Z3A7	Uncharacterized protein.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.440
W97_04934	W97_06720	R7YUU7	R7Z0K8	Uncharacterized protein.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.459
W97_04934	W97_07836	R7YUU7	R7Z3A7	Uncharacterized protein.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.581
W97_05990	W97_04364	R7YY80	R7YT88	Aminopeptidase.	POT family proton-dependent oligopeptide transporter.	0.412
W97_05990	W97_06720	R7YY80	R7Z0K8	Aminopeptidase.	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	0.449
W97_05990	W97_07836	R7YY80	R7Z3A7	Aminopeptidase.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.483
W97_06720	W97_00919	R7Z0K8	R7YIJ1	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	Uncharacterized protein.	0.449
W97_06720	W97_04934	R7Z0K8	R7YUU7	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	Uncharacterized protein.	0.459
W97_06720	W97_05990	R7Z0K8	R7YY80	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	Aminopeptidase.	0.449
W97_06720	W97_07836	R7Z0K8	R7Z3A7	Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	0.465
W97_07836	W97_00919	R7Z3A7	R7YIJ1	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	Uncharacterized protein.	0.483
W97_07836	W97_02175	R7Z3A7	R7YMA6	Cysteine proteinase 1, mitochondrial; Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.	Nudix hydrolase domain-containing protein.	0.643

page 1 of 2

Network Stats

number of nodes:

8

number of edges:

7

average node degree:

1.75

avg. local clustering coefficient:

0.875

expected number of edges:

7

PPI enrichment p-value:

0.587

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0095500

Acetylcholine receptor signaling pathway

3 of 10

2.81

2.51

2.47e-05

GO:0007178

Transmembrane receptor protein serine/threonine kinase signaling pathway

5 of 145

1.87

2.26

1.17e-05

GO:0007271

Synaptic transmission, cholinergic

3 of 27

2.38

2.04

0.00014

GO:0071363

Cellular response to growth factor stimulus

5 of 267

1.6

1.76

5.49e-05

GO:0045667

Regulation of osteoblast differentiation

3 of 52

2.09

1.61

0.00075

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004675

Transmembrane receptor protein serine/threonine kinase activity

4 of 21

2.61

3.23

8.48e-07

GO:0017002

Activin receptor activity

3 of 11

2.77

2.42

3.61e-05

GO:0048185

Activin binding

3 of 12

2.73

2.41

3.61e-05

GO:0016361

Activin receptor activity, type I

2 of 5

2.93

1.58

0.0014

GO:0016907

G protein-coupled acetylcholine receptor activity

2 of 6

2.85

1.54

0.0016

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0048179

Activin receptor complex

2 of 6

2.85

1.63

0.0011

GO:0043235

Receptor complex

4 of 365

1.37

1.03

0.0032

GO:0098802

Plasma membrane signaling receptor complex

3 of 165

1.59

1.03

0.0064

GO:0005887

Integral component of plasma membrane

7 of 1347

1.05

1.0

0.00017

GO:0030425

Dendrite

4 of 408

1.32

0.96

0.0043

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:31195646

(2019) Evolution and Medical Significance of LU Domain-Containing Proteins.

10 of 26

2.92

12.21

1.09e-24

PMID:37708126

(2023) Characterization of Fibrodysplasia Ossificans Progessiva relevant Acvr1Acvr2 Activin receptors in medaka (Oryzias latipes).

3 of 12

2.73

2.18

9.90e-05

PMID:31367467

(2019) Multiple functions of non-hypophysiotropic gonadotropin releasing hormone neurons in vertebrates.

3 of 18

2.55

2.01

0.00019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:34862

Muscarinic acetylcholine receptor family, and Acetylcholine receptor inhibitor activity

5 of 5

3.33

6.05

9.62e-12

CL:21463

TGF-beta signaling pathway

5 of 84

2.11

3.07

3.90e-07

CL:21464

SMAD protein signal transduction, and Activin binding

3 of 52

2.09

1.51

0.0012

CL:21575

Activin types I and II receptor domain, and Regulation of heart morphogenesis

2 of 6

2.85

1.38

0.0031

CL:21534

Activin receptor complex, and Negative regulation of growth rate

2 of 6

2.85

1.38

0.0031

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ola04350

TGF-beta signaling pathway

5 of 109

1.99

3.07

1.80e-07

ola04060

Cytokine-cytokine receptor interaction

4 of 185

1.67

1.74

0.00010

ola04810

Regulation of actin cytoskeleton

3 of 240

1.43

0.91

0.0092

ola04020

Calcium signaling pathway

3 of 263

1.39

0.89

0.0092

ola04080

Neuroactive ligand-receptor interaction

3 of 457

1.15

0.6

0.0358

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9006936

Signaling by TGFB family members

5 of 153

1.85

2.27

9.36e-06

MAP-201451

Signaling by BMP

3 of 37

2.24

1.69

0.00061

MAP-390648

Muscarinic acetylcholine receptors

2 of 6

2.85

1.38

0.0031

MAP-1502540

Signaling by Activin

2 of 21

2.31

0.92

0.0206

MAP-162582

Signal Transduction

8 of 4038

0.63

0.4

0.0247

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070724

BMP receptor complex

2 of 6

2.85

1.47

0.0022

GOCC:0048179

Activin receptor complex

2 of 6

2.85

1.47

0.0022

GOCC:0098802

Plasma membrane signaling receptor complex

4 of 160

1.73

1.4

0.0011

GOCC:0005887

Integral component of plasma membrane

4 of 429

1.3

0.89

0.0071

GOCC:0005886

Plasma membrane

8 of 2563

0.83

0.65

0.0018

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0628

Postsynaptic cell membrane

3 of 66

1.99

1.61

0.00065

KW-0675

Receptor

7 of 771

1.29

1.58

4.04e-06

KW-0723

Serine/threonine-protein kinase

4 of 288

1.47

1.32

0.00065

KW-0965

Cell junction

3 of 157

1.61

1.24

0.0020

KW-1003

Cell membrane

3 of 417

1.19

0.65

0.0278

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01064

Activin types I and II receptor domain

3 of 9

2.85

2.42

3.79e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR045860

Snake toxin-like superfamily

7 of 43

2.54

6.26

2.90e-13

IPR000333

Ser/Thr protein kinase, TGFB receptor

4 of 16

2.73

3.41

4.42e-07

IPR000995

Muscarinic acetylcholine receptor family

3 of 9

2.85

2.41

3.95e-05

IPR000472

Activin types I and II receptor domain

3 of 10

2.81

2.4

3.95e-05

IPR003605

GS domain

2 of 8

2.73

1.05

0.0127

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00467

GS motif

2 of 8

2.73

1.19

0.0069

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (30%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Cooccurrence

Textmining

Coexpression

© STRING Consortium 2025

Credits

Access

Info

About