Vbra_20591 protein (Vitrella brassicaformis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

Vbra_20591

Uncharacterized protein. (331 aa)

Predicted Functional Partners:

Vbra_4894

0.784

Vbra_14040

0.784

Vbra_22230

0.772

Vbra_13635

0.697

Vbra_7578

0.687

Vbra_14486

0.687

Vbra_14133

0.677

Vbra_3537

0.674

Vbra_19926

0.674

Vbra_6387

0.667

Your Current Organism:

Vitrella brassicaformis

NCBI taxonomy Id: 1169540
Other names: V. brassicaformis CCMP3155, Vitrella brassicaformis CCMP3155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Vbra_13635	Vbra_14040	A0A0G4EV47	A0A0G4F0L6	Uncharacterized protein.	IGPS domain-containing protein.	0.562
Vbra_13635	Vbra_20591	A0A0G4EV47	A0A0G4ENB1	Uncharacterized protein.	Uncharacterized protein.	0.697
Vbra_13635	Vbra_22230	A0A0G4EV47	A0A0G4GD90	Uncharacterized protein.	PALP domain-containing protein.	0.736
Vbra_13635	Vbra_4894	A0A0G4EV47	A0A0G4EE87	Uncharacterized protein.	Uncharacterized protein.	0.562
Vbra_14040	Vbra_13635	A0A0G4F0L6	A0A0G4EV47	IGPS domain-containing protein.	Uncharacterized protein.	0.562
Vbra_14040	Vbra_19926	A0A0G4F0L6	A0A0G4H8T0	IGPS domain-containing protein.	DJ-1_PfpI domain-containing protein.	0.501
Vbra_14040	Vbra_20591	A0A0G4F0L6	A0A0G4ENB1	IGPS domain-containing protein.	Uncharacterized protein.	0.784
Vbra_14040	Vbra_22230	A0A0G4F0L6	A0A0G4GD90	IGPS domain-containing protein.	PALP domain-containing protein.	0.994
Vbra_14040	Vbra_3537	A0A0G4F0L6	A0A0G4E938	IGPS domain-containing protein.	DJ-1_PfpI domain-containing protein.	0.501
Vbra_14040	Vbra_4894	A0A0G4F0L6	A0A0G4EE87	IGPS domain-containing protein.	Uncharacterized protein.	0.992
Vbra_14133	Vbra_14486	A0A0G4F1A6	A0A0G4F653	4-hydroxyphenylpyruvate dioxygenase.	Uncharacterized protein.	0.940
Vbra_14133	Vbra_20591	A0A0G4F1A6	A0A0G4ENB1	4-hydroxyphenylpyruvate dioxygenase.	Uncharacterized protein.	0.677
Vbra_14133	Vbra_22230	A0A0G4F1A6	A0A0G4GD90	4-hydroxyphenylpyruvate dioxygenase.	PALP domain-containing protein.	0.878
Vbra_14133	Vbra_7578	A0A0G4F1A6	A0A0G4EI01	4-hydroxyphenylpyruvate dioxygenase.	Uncharacterized protein.	0.940
Vbra_14486	Vbra_14133	A0A0G4F653	A0A0G4F1A6	Uncharacterized protein.	4-hydroxyphenylpyruvate dioxygenase.	0.940
Vbra_14486	Vbra_20591	A0A0G4F653	A0A0G4ENB1	Uncharacterized protein.	Uncharacterized protein.	0.687
Vbra_19926	Vbra_14040	A0A0G4H8T0	A0A0G4F0L6	DJ-1_PfpI domain-containing protein.	IGPS domain-containing protein.	0.501
Vbra_19926	Vbra_20591	A0A0G4H8T0	A0A0G4ENB1	DJ-1_PfpI domain-containing protein.	Uncharacterized protein.	0.674
Vbra_19926	Vbra_22230	A0A0G4H8T0	A0A0G4GD90	DJ-1_PfpI domain-containing protein.	PALP domain-containing protein.	0.815
Vbra_19926	Vbra_4894	A0A0G4H8T0	A0A0G4EE87	DJ-1_PfpI domain-containing protein.	Uncharacterized protein.	0.501

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

51

average node degree:

9.27

avg. local clustering coefficient:

0.927

expected number of edges:

15

PPI enrichment p-value:

7.84e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000398

mRNA splicing, via spliceosome

11 of 275

2.2

8.01

3.58e-21

GO:0022618

Ribonucleoprotein complex assembly

3 of 182

1.81

1.29

0.0024

GO:0000387

Spliceosomal snRNP assembly

2 of 29

2.44

1.26

0.0047

GO:0000245

Spliceosomal complex assembly

2 of 49

2.21

1.03

0.0123

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

7 of 1120

1.39

1.75

4.32e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0071013

Catalytic step 2 spliceosome

10 of 161

2.39

8.97

3.29e-21

GO:0005681

Spliceosomal complex

11 of 278

2.19

8.16

8.18e-22

GO:0071007

U2-type catalytic step 2 spliceosome

4 of 30

2.72

4.25

1.00e-08

GO:0000974

Prp19 complex

4 of 30

2.72

4.25

1.00e-08

GO:0005684

U2-type spliceosomal complex

5 of 113

2.24

3.93

7.75e-09

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7916

Mixed, incl. Prp19 complex, and Cwf19-like protein

8 of 14

3.35

11.45

7.10e-22

CL:7918

Mixed, incl. Positive regulation of RNA splicing, and Post-spliceosomal complex

5 of 7

3.45

7.23

7.06e-14

CL:8120

U2 snRNP, and SF3B4, RNA recognition motif 1

3 of 29

2.61

1.40e-05

CL:8121

U2 snRNP, and SF3B4, RNA recognition motif 1

2 of 23

2.54

1.37

0.0030

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

aqu03040

Spliceosome

11 of 109

2.6

12.05

5.44e-27

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72172

mRNA Splicing

11 of 354

2.09

7.25

1.25e-20

MAP-72163

mRNA Splicing - Major Pathway

10 of 328

2.08

6.64

2.55e-18

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 476

1.96

6.26

1.55e-19

MAP-8953854

Metabolism of RNA

11 of 1040

1.62

3.89

3.89e-16

MAP-6781823

Formation of TC-NER Pre-Incision Complex

4 of 92

2.23

2.93

1.44e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005681

Spliceosomal complex

6 of 148

2.2

4.38

4.56e-10

GOCC:0000974

Prp19 complex

4 of 29

2.74

4.06

2.52e-08

GOCC:1990904

Ribonucleoprotein complex

8 of 488

1.81

3.78

4.87e-11

GOCC:0071013

Catalytic step 2 spliceosome

4 of 42

2.58

3.73

8.04e-08

GOCC:0005634

Nucleus

8 of 2291

1.14

1.36

1.61e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0508

mRNA splicing

2 of 22

2.56

1.3

0.0041

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