Vbra_9105 protein (Vitrella brassicaformis) - STRING interaction network

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

Vbra_9105

Protein-serine/threonine kinase. (485 aa)

Predicted Functional Partners:

Vbra_20387

0.795

Vbra_8768

0.740

Vbra_13704

0.714

Vbra_11377

0.634

Vbra_14476

0.634

Vbra_15577

0.634

Vbra_22687

0.634

Vbra_6310

0.634

Vbra_3010

0.625

Vbra_18040

0.625

Your Current Organism:

Vitrella brassicaformis

NCBI taxonomy Id: 1169540
Other names: V. brassicaformis CCMP3155, Vitrella brassicaformis CCMP3155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Vbra_11377	Vbra_14476	A0A0G4EED7	A0A0G4F6A7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_11377	Vbra_15577	A0A0G4EED7	A0A0G4FJG7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_11377	Vbra_22687	A0A0G4EED7	A0A0G4G6B0	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_11377	Vbra_6310	A0A0G4EED7	A0A0G4GMQ7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_11377	Vbra_9105	A0A0G4EED7	A0A0G4FF11	Uncharacterized protein.	Protein-serine/threonine kinase.	0.634
Vbra_13704	Vbra_20387	A0A0G4EVX8	A0A0G4EJ84	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.997
Vbra_13704	Vbra_8768	A0A0G4EVX8	A0A0G4F429	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
Vbra_13704	Vbra_9105	A0A0G4EVX8	A0A0G4FF11	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Protein-serine/threonine kinase.	0.714
Vbra_14476	Vbra_11377	A0A0G4F6A7	A0A0G4EED7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_14476	Vbra_15577	A0A0G4F6A7	A0A0G4FJG7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_14476	Vbra_22687	A0A0G4F6A7	A0A0G4G6B0	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_14476	Vbra_6310	A0A0G4F6A7	A0A0G4GMQ7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_14476	Vbra_9105	A0A0G4F6A7	A0A0G4FF11	Uncharacterized protein.	Protein-serine/threonine kinase.	0.634
Vbra_15577	Vbra_11377	A0A0G4FJG7	A0A0G4EED7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_15577	Vbra_14476	A0A0G4FJG7	A0A0G4F6A7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_15577	Vbra_22687	A0A0G4FJG7	A0A0G4G6B0	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_15577	Vbra_6310	A0A0G4FJG7	A0A0G4GMQ7	Uncharacterized protein.	Uncharacterized protein.	0.727
Vbra_15577	Vbra_9105	A0A0G4FJG7	A0A0G4FF11	Uncharacterized protein.	Protein-serine/threonine kinase.	0.634
Vbra_18040	Vbra_20387	A0A0G4GJP6	A0A0G4EJ84	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.636
Vbra_18040	Vbra_9105	A0A0G4GJP6	A0A0G4FF11	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	Protein-serine/threonine kinase.	0.625

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Network Stats

number of nodes:

5

number of edges:

6

average node degree:

2.4

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.763

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0043966

Histone H3 acetylation

9 of 33

2.51

8.17

6.66e-18

GO:0018205

Peptidyl-lysine modification

10 of 166

1.86

4.91

1.96e-15

GO:0016570

Histone modification

10 of 223

1.73

4.13

2.68e-14

GO:0043983

Histone H4-K12 acetylation

4 of 5

2.98

4.12

2.63e-08

GO:0044154

Histone H3-K14 acetylation

4 of 8

2.77

3.79

8.72e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010698

Acetyltransferase activator activity

2 of 3

2.9

1.07

0.0119

GO:0042393

Histone binding

4 of 144

1.52

0.9

0.0119

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070776

MOZ/MORF histone acetyltransferase complex

6 of 8

2.95

7.03

6.18e-14

GO:0000123

Histone acetyltransferase complex

9 of 57

2.27

7.01

8.09e-17

GO:0035267

NuA4 histone acetyltransferase complex

2 of 17

2.15

1.1

0.0085

GO:0005634

Nucleus

11 of 4187

0.5

0.42

0.00038

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4439

Histone H4 acetylation, and H3 histone acetyltransferase complex

9 of 31

2.54

8.53

1.30e-18

CL:4484

Enhancer of polycomb-like, and ING family

6 of 7

3.01

6.96

1.02e-13

CL:4121

Mixed, incl. Chromatin organization, and Nucleosome

10 of 190

1.8

4.53

8.10e-15

CL:4442

Histone H2A acetylation, and Germ-line stem cell division

3 of 15

2.38

1.92

0.00024

CL:4444

Histone H2A acetylation

2 of 10

2.38

0.94

0.0192

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6804758

Regulation of TP53 Activity through Acetylation

5 of 16

2.57

4.33

4.70e-09

MAP-5633007

Regulation of TP53 Activity

5 of 90

1.82

2.3

6.51e-06

MAP-3700989

Transcriptional Regulation by TP53

5 of 241

1.39

1.28

0.00051

MAP-3214847

HATs acetylate histones

3 of 54

1.82

1.23

0.0034

MAP-4839726

Chromatin organization

4 of 144

1.52

1.19

0.0020

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000123

Histone acetyltransferase complex

10 of 49

2.39

8.66

2.32e-20

GOCC:0070775

H3 histone acetyltransferase complex

5 of 9

2.82

5.52

3.96e-11

GOCC:0070776

MOZ/MORF histone acetyltransferase complex

4 of 5

2.98

4.56

3.90e-09

GOCC:0005654

Nucleoplasm

11 of 385

1.53

3.35

5.79e-15

GOCC:1902494

Catalytic complex

11 of 943

1.14

1.68

3.96e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0103

Bromodomain

3 of 23

2.19

2.02

0.00012

KW-0863

Zinc-finger

7 of 640

1.11

1.15

5.60e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10513

Enhancer of polycomb-like

5 of 8

2.87

5.11

2.83e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019787

Zinc finger, PHD-finger

7 of 45

2.27

5.05

1.67e-11

IPR001965

Zinc finger, PHD-type

7 of 60

2.14

4.61

5.40e-11

IPR019786

Zinc finger, PHD-type, conserved site

6 of 40

2.25

4.36

7.64e-10

IPR034732

Extended PHD (ePHD) domain

5 of 22

2.43

4.04

1.16e-08

IPR011011

Zinc finger, FYVE/PHD-type

7 of 84

2.0

4.03

3.33e-10

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00249

PHD zinc finger

7 of 54

2.19

5.03

6.96e-12

SM00293

Domain with conserved PWWP motif

3 of 9

2.6

2.43

3.11e-05

SM00297

Bromo domain

3 of 23

2.19

1.88

0.00024

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