Vbra_1739 protein (Vitrella brassicaformis) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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Score

Vbra_1739

Uncharacterized protein. (615 aa)

Predicted Functional Partners:

Vbra_13635

0.726

Vbra_3288

0.526

Vbra_13390

0.525

Vbra_18155

0.523

Vbra_7705

0.516

Vbra_10400

0.493

Vbra_7324

0.473

Vbra_15005

0.460

Vbra_17964

0.460

Vbra_2992

0.452

Your Current Organism:

Vitrella brassicaformis

NCBI taxonomy Id: 1169540
Other names: V. brassicaformis CCMP3155, Vitrella brassicaformis CCMP3155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Vbra_10400	Vbra_13635	A0A0G4GUI4	A0A0G4EV47	Flavodoxin-like domain-containing protein.	Uncharacterized protein.	0.906
Vbra_10400	Vbra_1739	A0A0G4GUI4	A0A0G4FQS5	Flavodoxin-like domain-containing protein.	Uncharacterized protein.	0.493
Vbra_13390	Vbra_15005	A0A0G4EUS8	A0A0G4FCV3	Aminotran_5 domain-containing protein.	AA_kinase domain-containing protein.	0.669
Vbra_13390	Vbra_1739	A0A0G4EUS8	A0A0G4FQS5	Aminotran_5 domain-containing protein.	Uncharacterized protein.	0.525
Vbra_13390	Vbra_17964	A0A0G4EUS8	A0A0G4GJJ1	Aminotran_5 domain-containing protein.	Homoserine dehydrogenase.	0.669
Vbra_13635	Vbra_10400	A0A0G4EV47	A0A0G4GUI4	Uncharacterized protein.	Flavodoxin-like domain-containing protein.	0.906
Vbra_13635	Vbra_1739	A0A0G4EV47	A0A0G4FQS5	Uncharacterized protein.	Uncharacterized protein.	0.726
Vbra_13635	Vbra_18155	A0A0G4EV47	A0A0G4GKP0	Uncharacterized protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.619
Vbra_13635	Vbra_7705	A0A0G4EV47	A0A0G4ELA5	Uncharacterized protein.	Uncharacterized protein.	0.734
Vbra_15005	Vbra_13390	A0A0G4FCV3	A0A0G4EUS8	AA_kinase domain-containing protein.	Aminotran_5 domain-containing protein.	0.669
Vbra_15005	Vbra_1739	A0A0G4FCV3	A0A0G4FQS5	AA_kinase domain-containing protein.	Uncharacterized protein.	0.460
Vbra_15005	Vbra_18155	A0A0G4FCV3	A0A0G4GKP0	AA_kinase domain-containing protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.650
Vbra_15005	Vbra_3288	A0A0G4FCV3	A0A0G4G959	AA_kinase domain-containing protein.	Semialdhyde_dh domain-containing protein.	0.925
Vbra_1739	Vbra_10400	A0A0G4FQS5	A0A0G4GUI4	Uncharacterized protein.	Flavodoxin-like domain-containing protein.	0.493
Vbra_1739	Vbra_13390	A0A0G4FQS5	A0A0G4EUS8	Uncharacterized protein.	Aminotran_5 domain-containing protein.	0.525
Vbra_1739	Vbra_13635	A0A0G4FQS5	A0A0G4EV47	Uncharacterized protein.	Uncharacterized protein.	0.726
Vbra_1739	Vbra_15005	A0A0G4FQS5	A0A0G4FCV3	Uncharacterized protein.	AA_kinase domain-containing protein.	0.460
Vbra_1739	Vbra_17964	A0A0G4FQS5	A0A0G4GJJ1	Uncharacterized protein.	Homoserine dehydrogenase.	0.460
Vbra_1739	Vbra_18155	A0A0G4FQS5	A0A0G4GKP0	Uncharacterized protein.	Bifunctional dihydrofolate reductase-thymidylate synthase; Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism; In the C-terminal section; belongs to the thymidylate synthase family.	0.523
Vbra_1739	Vbra_2992	A0A0G4FQS5	A0A0G4EPH9	Uncharacterized protein.	Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.	0.452

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Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.905

expected number of edges:

14

PPI enrichment p-value:

1.3e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0044038

Cell wall macromolecule biosynthetic process

8 of 29

1.71

3.22

7.08e-10

GO:0009273

Peptidoglycan-based cell wall biogenesis

8 of 30

1.69

3.18

7.08e-10

GO:0071555

Cell wall organization

7 of 24

1.73

3.12

3.50e-09

GO:0009252

Peptidoglycan biosynthetic process

6 of 20

1.74

2.79

7.96e-08

GO:0051301

Cell division

7 of 32

1.61

2.67

1.57e-08

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016881

Acid-amino acid ligase activity

4 of 8

1.97

1.94

0.00011

GO:0016874

Ligase activity

5 of 75

1.09

0.76

0.0077

GO:0043168

Anion binding

8 of 334

0.65

0.46

0.0084

GO:0036094

Small molecule binding

8 of 352

0.62

0.44

0.0086

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1122

Peptidoglycan synthesis, and PASTA domain

8 of 12

2.09

5.14

6.38e-13

CL:1121

Cell cycle, and D-Alanine metabolism

9 of 21

1.9

4.64

2.12e-13

CL:1125

Peptidoglycan synthesis, and PASTA domain

4 of 6

2.09

2.58

5.50e-06

CL:1907

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

0.81

0.0285

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

lai00550

Peptidoglycan biosynthesis

7 of 17

1.88

3.76

3.21e-10

lai00473

D-Alanine metabolism

4 of 4

2.27

2.97

1.34e-06

lai01502

Vancomycin resistance

4 of 5

2.17

2.87

1.61e-06

lai00471

D-Glutamine and D-glutamate metabolism

2 of 4

1.97

1.13

0.0067

lai01503

Cationic antimicrobial peptide (CAMP) resistance

2 of 5

1.87

1.08

0.0078

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

7 of 13

2.0

4.16

1.32e-10

KW-0573

Peptidoglycan synthesis

6 of 11

2.0

3.67

4.31e-09

KW-0132

Cell division

6 of 30

1.57

2.3

3.26e-07

KW-0131

Cell cycle

6 of 30

1.57

2.3

3.26e-07

KW-0436

Ligase

6 of 63

1.25

1.43

1.25e-05

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02875

Mur ligase family, glutamate ligase domain

3 of 5

2.05

1.41

0.0019

PF08245

Mur ligase middle domain

3 of 6

1.97

1.39

0.0019

PF01225

Mur ligase family, catalytic domain

2 of 2

2.27

0.97

0.0158

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036615

Mur ligase, C-terminal domain superfamily

3 of 5

2.05

1.18

0.0055

IPR036565

Mur-like, catalytic domain superfamily

3 of 6

1.97

1.17

0.0055

IPR013221

Mur ligase, central

3 of 6

1.97

1.17

0.0055

IPR000713

Mur ligase, N-terminal catalytic domain

2 of 2

2.27

0.8

0.0338

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