Vbra_3307 protein (Vitrella brassicaformis) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

Vbra_3307

F-BAR domain-containing protein. (890 aa)

Predicted Functional Partners:

Vbra_3720

0.961

Vbra_21293

0.896

Vbra_19754

0.686

Vbra_18402

0.617

Vbra_2506

0.580

Vbra_21855

0.565

Vbra_4933

0.562

Vbra_4906

0.562

Vbra_7825

0.562

Vbra_20709

0.562

Your Current Organism:

Vitrella brassicaformis

NCBI taxonomy Id: 1169540
Other names: V. brassicaformis CCMP3155, Vitrella brassicaformis CCMP3155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Vbra_18402	Vbra_20709	A0A0G4GR77	A0A0G4EPB7	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.795
Vbra_18402	Vbra_21293	A0A0G4GR77	A0A0G4FI45	Protein kinase domain-containing protein.	Uncharacterized protein.	0.710
Vbra_18402	Vbra_21855	A0A0G4GR77	A0A0G4G046	Protein kinase domain-containing protein.	Uncharacterized protein.	0.795
Vbra_18402	Vbra_2506	A0A0G4GR77	A0A0G4F5X3	Protein kinase domain-containing protein.	Uncharacterized protein.	0.795
Vbra_18402	Vbra_3307	A0A0G4GR77	A0A0G4G8D1	Protein kinase domain-containing protein.	F-BAR domain-containing protein.	0.617
Vbra_18402	Vbra_3720	A0A0G4GR77	A0A0G4EFT4	Protein kinase domain-containing protein.	Uncharacterized protein.	0.957
Vbra_18402	Vbra_4906	A0A0G4GR77	A0A0G4EFC9	Protein kinase domain-containing protein.	GPN-loop GTPase 2; Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	0.795
Vbra_18402	Vbra_4933	A0A0G4GR77	A0A0G4EDS3	Protein kinase domain-containing protein.	J domain-containing protein.	0.795
Vbra_18402	Vbra_7825	A0A0G4GR77	A0A0G4EML2	Protein kinase domain-containing protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.795
Vbra_19754	Vbra_21293	A0A0G4H796	A0A0G4FI45	SH3 domain-containing protein.	Uncharacterized protein.	0.982
Vbra_19754	Vbra_3307	A0A0G4H796	A0A0G4G8D1	SH3 domain-containing protein.	F-BAR domain-containing protein.	0.686
Vbra_19754	Vbra_3720	A0A0G4H796	A0A0G4EFT4	SH3 domain-containing protein.	Uncharacterized protein.	0.401
Vbra_20709	Vbra_18402	A0A0G4EPB7	A0A0G4GR77	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Protein kinase domain-containing protein.	0.795
Vbra_20709	Vbra_21293	A0A0G4EPB7	A0A0G4FI45	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.696
Vbra_20709	Vbra_3307	A0A0G4EPB7	A0A0G4G8D1	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	F-BAR domain-containing protein.	0.562
Vbra_20709	Vbra_3720	A0A0G4EPB7	A0A0G4EFT4	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	Uncharacterized protein.	0.977
Vbra_21293	Vbra_18402	A0A0G4FI45	A0A0G4GR77	Uncharacterized protein.	Protein kinase domain-containing protein.	0.710
Vbra_21293	Vbra_19754	A0A0G4FI45	A0A0G4H796	Uncharacterized protein.	SH3 domain-containing protein.	0.982
Vbra_21293	Vbra_20709	A0A0G4FI45	A0A0G4EPB7	Uncharacterized protein.	Uncharacterized protein; Belongs to the small GTPase superfamily. Arf family.	0.696
Vbra_21293	Vbra_21855	A0A0G4FI45	A0A0G4G046	Uncharacterized protein.	Uncharacterized protein.	0.719

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

33

average node degree:

6

avg. local clustering coefficient:

0.923

expected number of edges:

10

PPI enrichment p-value:

1.17e-08

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0010965

Regulation of mitotic sister chromatid separation

6 of 27

2.06

3.42

3.70e-08

GO:0033045

Regulation of sister chromatid segregation

6 of 30

2.01

3.35

3.70e-08

GO:0031145

Anaphase-promoting complex-dependent catabolic process

4 of 13

2.2

2.53

1.01e-05

GO:0030071

Regulation of mitotic metaphase/anaphase transition

4 of 25

1.91

2.05

4.99e-05

GO:0007094

Mitotic spindle assembly checkpoint signaling

3 of 16

1.98

1.58

0.00075

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019003

GDP binding

2 of 3

2.53

0.73

0.0467

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005680

Anaphase-promoting complex

5 of 15

2.23

3.41

1.17e-07

GO:0140535

Intracellular protein-containing complex

6 of 382

0.91

0.66

0.0055

GO:0140513

Nuclear protein-containing complex

6 of 580

0.72

0.42

0.0402

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2016

Anaphase-promoting complex, and Inactivation of APC/C via direct inhibition of the APC/C complex

8 of 22

2.27

6.05

3.99e-14

CL:2017

Anaphase-promoting complex, and APC-Cdc20 mediated degradation of Nek2A

6 of 17

2.26

4.65

1.56e-10

CL:2021

Anaphase-promoting complex-dependent catabolic process

5 of 11

2.37

4.13

5.57e-09

CL:2025

Anaphase-promoting complex-dependent catabolic process

3 of 6

2.41

2.26

5.43e-05

CL:2050

Mitotic checkpoint complex, and Mad3/Bub1 homology region 1

2 of 5

2.31

1.14

0.0077

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04113

Meiosis - yeast

10 of 106

1.68

3.99

1.40e-14

map04111

Cell cycle - yeast

8 of 108

1.58

2.92

2.79e-10

map04120

Ubiquitin mediated proteolysis

5 of 85

1.48

1.74

1.88e-05

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-141430

Inactivation of APC/C via direct inhibition of the APC/C complex

3 of 8

2.28

1.88

0.00027

MAP-141405

Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components

3 of 8

2.28

1.88

0.00027

MAP-176408

Regulation of APC/C activators between G1/S and early anaphase

3 of 13

2.07

1.7

0.00048

MAP-453276

Regulation of mitotic cell cycle

3 of 17

1.96

1.56

0.00079

MAP-174143

APC/C-mediated degradation of cell cycle proteins

3 of 17

1.96

1.56

0.00079

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005680

Anaphase-promoting complex

4 of 10

2.31

2.66

7.05e-06

GOCC:0033597

Mitotic checkpoint complex

3 of 4

2.58

2.28

5.83e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12895

Anaphase-promoting complex, cyclosome, subunit 3

2 of 2

2.71

0.98

0.0166

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00777

Mad3/BUB1 hoMad3/BUB1 homology region 1

2 of 2

2.71

1.22

0.0061

SM00173

Ras subfamily of RAS small GTPases

2 of 4

2.41

1.15

0.0076

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