Vbra_18016 protein (Vitrella brassicaformis)

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

Vbra_18016

Uncharacterized protein. (533 aa)

Predicted Functional Partners:

Vbra_14623

0.574

Vbra_21786

0.574

Vbra_430

0.574

Vbra_6816

0.553

Vbra_9782

0.553

Vbra_21892

0.535

Vbra_12497

0.528

Vbra_8086

0.528

Vbra_14474

0.528

Vbra_8947

0.528

Your Current Organism:

Vitrella brassicaformis

NCBI taxonomy Id: 1169540
Other names: V. brassicaformis CCMP3155, Vitrella brassicaformis CCMP3155

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Vbra_12497	Vbra_14474	A0A0G4EN71	A0A0G4F507	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.904
Vbra_12497	Vbra_14623	A0A0G4EN71	A0A0G4F771	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.888
Vbra_12497	Vbra_18016	A0A0G4EN71	A0A0G4GJN6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.528
Vbra_12497	Vbra_21786	A0A0G4EN71	A0A0G4FXS4	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.895
Vbra_12497	Vbra_21892	A0A0G4EN71	A0A0G4G293	Ubiquitin-like domain-containing protein.	E2_bind domain-containing protein.	0.704
Vbra_12497	Vbra_430	A0A0G4EN71	A0A0G4GVP6	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.884
Vbra_12497	Vbra_6816	A0A0G4EN71	A0A0G4EAQ7	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.642
Vbra_12497	Vbra_9782	A0A0G4EN71	A0A0G4G9M8	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.642
Vbra_14474	Vbra_12497	A0A0G4F507	A0A0G4EN71	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.904
Vbra_14474	Vbra_14623	A0A0G4F507	A0A0G4F771	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.888
Vbra_14474	Vbra_18016	A0A0G4F507	A0A0G4GJN6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.528
Vbra_14474	Vbra_21786	A0A0G4F507	A0A0G4FXS4	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.894
Vbra_14474	Vbra_21892	A0A0G4F507	A0A0G4G293	Ubiquitin-like domain-containing protein.	E2_bind domain-containing protein.	0.704
Vbra_14474	Vbra_430	A0A0G4F507	A0A0G4GVP6	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.884
Vbra_14474	Vbra_6816	A0A0G4F507	A0A0G4EAQ7	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.642
Vbra_14474	Vbra_9782	A0A0G4F507	A0A0G4G9M8	Ubiquitin-like domain-containing protein.	CULLIN_2 domain-containing protein; Belongs to the cullin family.	0.642
Vbra_14623	Vbra_12497	A0A0G4F771	A0A0G4EN71	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.888
Vbra_14623	Vbra_14474	A0A0G4F771	A0A0G4F507	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.888
Vbra_14623	Vbra_18016	A0A0G4F771	A0A0G4GJN6	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.574
Vbra_14623	Vbra_21892	A0A0G4F771	A0A0G4G293	Ubiquitin-like domain-containing protein.	E2_bind domain-containing protein.	0.677

page 1 of 5

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.0522

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0099560

Synaptic membrane adhesion

5 of 12

2.84

4.76

1.30e-09

GO:0035335

Peptidyl-tyrosine dephosphorylation

4 of 27

2.39

2.73

5.75e-06

GO:0019221

Cytokine-mediated signaling pathway

6 of 181

1.74

2.39

1.81e-06

GO:0097374

Sensory neuron axon guidance

2 of 4

2.92

1.36

0.0035

GO:0070498

interleukin-1-mediated signaling pathway

2 of 7

2.68

1.21

0.0062

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004908

interleukin-1 receptor activity

4 of 4

3.22

4.35

1.23e-08

GO:0061809

NAD+ nucleotidase, cyclic ADP-ribose generating

3 of 15

2.52

2.13

0.00011

GO:0050135

NAD(P)+ nucleosidase activity

3 of 15

2.52

2.13

0.00011

GO:0004725

Protein tyrosine phosphatase activity

4 of 97

1.84

1.86

0.00011

GO:0008201

Heparin binding

4 of 114

1.77

1.75

0.00016

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:34025644

(2021) Modeling Virus-Induced Inflammation in Zebrafish: A Balance Between Infection Control and Excessive Inflammation.

3 of 39

2.11

1.48

0.0014

PMID:27231948

(2016) The Function of Fish Cytokines.

3 of 40

2.1

1.48

0.0014

PMID:35371107

(2022) Transcriptome Sequencing Reveals the Antiviral Innate Immunity by IFN-gamma in Chinese Sturgeon Macrophages.

2 of 12

2.44

1.16

0.0075

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4439

NAD+ nucleosidase activity, and interleukin-1-mediated signaling pathway

6 of 17

2.77

6.02

3.38e-12

CL:4443

interleukin-1-mediated signaling pathway, and Inflammatory response

4 of 5

3.13

4.47

6.78e-09

CL:7095

Receptor-type tyrosine-protein phosphatases, and Synaptic membrane adhesion

4 of 21

2.5

3.38

3.39e-07

CL:7097

Synaptic membrane adhesion, and Presynaptic membrane assembly

3 of 13

2.59

2.46

2.65e-05

CL:7099

Synaptic membrane adhesion, and NTF3 activates NTRK3 signaling

2 of 5

2.82

1.53

0.0017

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

4 of 105

1.8

1.9

7.30e-05

map04910

Insulin signaling pathway

4 of 157

1.63

1.68

0.00012

map04620

Toll-like receptor signaling pathway

3 of 91

1.74

1.49

0.00067

map04514

Cell adhesion molecules

4 of 210

1.5

1.46

0.00027

map04010

MAPK signaling pathway

5 of 361

1.36

1.41

0.00012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-388844

Receptor-type tyrosine-protein phosphatases

5 of 24

2.54

4.43

2.60e-09

MAP-446652

Interleukin-1 family signaling

7 of 108

2.03

4.21

1.69e-10

MAP-8849932

Synaptic adhesion-like molecules

4 of 21

2.5

3.37

3.63e-07

MAP-6794362

Protein-protein interactions at synapses

5 of 89

1.97

2.89

4.72e-07

MAP-9020702

Interleukin-1 signaling

5 of 95

1.94

2.83

5.39e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0904

Protein phosphatase

3 of 70

1.85

1.25

0.0032

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR004074

Interleukin-1 receptor type I/II

4 of 7

2.98

3.72

1.52e-07

IPR015621

Interleukin-1 receptor family

4 of 10

2.82

3.59

2.31e-07

IPR000157

Toll/interleukin-1 receptor homology (TIR) domain

3 of 29

2.24

1.68

0.00065

IPR035897

Toll/interleukin-1 receptor homology (TIR) domain superfamily

3 of 31

2.21

1.65

0.00070

IPR003598

Immunoglobulin subtype 2

5 of 245

1.53

1.52

0.00021

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00194

Protein tyrosine phosphatase, catalytic domain

3 of 39

2.11

1.59

0.00085

SM00409

Immunoglobulin

5 of 351

1.38

1.2

0.00085

SM00255

Toll - interleukin 1 - resistance

2 of 14

2.38

1.09

0.0098

SM00408

Immunoglobulin C-2 Type

3 of 206

1.39

0.67

0.0378

SM00060

Fibronectin type 3 domain

3 of 198

1.4

0.67

0.0378

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