STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PLEKHG2Pleckstrin homology domain-containing family G member 2 isoform X1. (1445 aa)    
Predicted Functional Partners:
PIK3R3
Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.
    
 0.587
LGI4
Leucine-rich repeat LGI family member 4.
      
 0.557
CDC42
Cell division control protein 42 homolog isoform X2.
    
 0.460
SUPT5H
Transcription elongation factor SPT5.
    
 0.459
PLCE1
Phosphoinositide phospholipase C.
      
 0.439
IL33
Interleukin-33 isoform X1.
  
     0.435
TMEM190
Transmembrane protein 190.
  
     0.414
Your Current Organism:
Ursus arctos
NCBI taxonomy Id: 116960
Other names: U. arctos horribilis, Ursus arctos horribilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.