STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BEST1Bestrophin; Forms calcium-sensitive chloride channels. Permeable to bicarbonate; Belongs to the bestrophin family. (588 aa)    
Predicted Functional Partners:
MERTK
Tyrosine-protein kinase Mer.
      
 0.597
RPE65
Retinoid isomerohydrolase.
      
 0.596
GLUL
Glutamine synthetase.
    
 
 0.540
MITF
Microphthalmia-associated transcription factor isoform X1.
      
 0.529
RLBP1
Retinaldehyde-binding protein 1.
   
  
 0.512
RDH5
11-cis retinol dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.510
PPP1R32
Protein phosphatase 1 regulatory subunit 32.
      
 0.509
TMEM98
Transmembrane protein 98.
      
 0.502
PDE6A
Phosphodiesterase.
   
  
 0.465
LRRC8A
Volume-regulated anion channel subunit LRRC8A.
      
 0.459
Your Current Organism:
Ursus arctos
NCBI taxonomy Id: 116960
Other names: U. arctos horribilis, Ursus arctos horribilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.