HSF4 protein (Ursus arctos) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

HSF4

Heat shock factor protein 4 isoform X1. (515 aa)

Predicted Functional Partners:

HSPB2

0.668

CRYAB

0.646

PTGES3

0.635

SIRT1

0.602

CRYAA

0.594

LOC113248717

0.593

YWHAE

0.580

BPNT1

0.579

LOC113252319

0.578

HSP90AA1

0.578

Your Current Organism:

Ursus arctos

NCBI taxonomy Id: 116960
Other names: U. arctos horribilis, Ursus arctos horribilis

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BPNT1	HSF4	A0A3Q7XZT2	A0A3Q7VP22	3'(2'),5'-bisphosphate nucleotidase 1.	Heat shock factor protein 4 isoform X1.	0.579
CRYAA	CRYAB	A0A3Q7WXK1	A0A3Q7X4T0	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.975
CRYAA	HSF4	A0A3Q7WXK1	A0A3Q7VP22	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock factor protein 4 isoform X1.	0.594
CRYAA	LOC113248717	A0A3Q7WXK1	A0A3Q7VTY2	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Gamma-crystallin C isoform X1; Belongs to the beta/gamma-crystallin family.	0.663
CRYAB	CRYAA	A0A3Q7X4T0	A0A3Q7WXK1	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.975
CRYAB	HSF4	A0A3Q7X4T0	A0A3Q7VP22	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock factor protein 4 isoform X1.	0.646
CRYAB	HSP90AA1	A0A3Q7X4T0	A0A3Q7WDA7	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein HSP 90-alpha.	0.446
CRYAB	HSPB2	A0A3Q7X4T0	A0A3Q7XG84	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein beta-2; Belongs to the small heat shock protein (HSP20) family.	0.686
CRYAB	LOC113248717	A0A3Q7X4T0	A0A3Q7VTY2	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Gamma-crystallin C isoform X1; Belongs to the beta/gamma-crystallin family.	0.584
CRYAB	LOC113252319	A0A3Q7X4T0	A0A3Q7VEY7	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	Heat shock protein HSP 90-alpha-like.	0.446
HSF4	BPNT1	A0A3Q7VP22	A0A3Q7XZT2	Heat shock factor protein 4 isoform X1.	3'(2'),5'-bisphosphate nucleotidase 1.	0.579
HSF4	CRYAA	A0A3Q7VP22	A0A3Q7WXK1	Heat shock factor protein 4 isoform X1.	Alpha-crystallin A chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.594
HSF4	CRYAB	A0A3Q7VP22	A0A3Q7X4T0	Heat shock factor protein 4 isoform X1.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.	0.646
HSF4	HSP90AA1	A0A3Q7VP22	A0A3Q7WDA7	Heat shock factor protein 4 isoform X1.	Heat shock protein HSP 90-alpha.	0.578
HSF4	HSPB2	A0A3Q7VP22	A0A3Q7XG84	Heat shock factor protein 4 isoform X1.	Heat shock protein beta-2; Belongs to the small heat shock protein (HSP20) family.	0.668
HSF4	LOC113248717	A0A3Q7VP22	A0A3Q7VTY2	Heat shock factor protein 4 isoform X1.	Gamma-crystallin C isoform X1; Belongs to the beta/gamma-crystallin family.	0.593
HSF4	LOC113252319	A0A3Q7VP22	A0A3Q7VEY7	Heat shock factor protein 4 isoform X1.	Heat shock protein HSP 90-alpha-like.	0.578
HSF4	PTGES3	A0A3Q7VP22	A0A3Q7V425	Heat shock factor protein 4 isoform X1.	Prostaglandin E synthase 3.	0.635
HSF4	SIRT1	A0A3Q7VP22	A0A3Q7WEP8	Heat shock factor protein 4 isoform X1.	NAD-dependent protein deacetylase sirtuin-1 isoform X1.	0.602
HSF4	YWHAE	A0A3Q7VP22	A0A3Q7Y0Q2	Heat shock factor protein 4 isoform X1.	14-3-3 protein epsilon; Belongs to the 14-3-3 family.	0.580