STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LOC113265123L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)    
Predicted Functional Partners:
GOT2
Aspartate aminotransferase.
   
 0.960
GOT1
Aspartate aminotransferase.
   
 0.959
PKM
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.957
PKLR
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.956
PC
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
  
 0.951
GOT1L1
Putative aspartate aminotransferase, cytoplasmic 2.
   
 0.942
ME1
Malic enzyme.
  
 0.933
ME2
Malic enzyme.
  
 0.933
ME3
Malic enzyme.
  
 0.933
PDHB
Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
   
 0.928
Your Current Organism:
Ursus arctos
NCBI taxonomy Id: 116960
Other names: U. arctos horribilis, Ursus arctos horribilis
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.