STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ROS1Tyrosine-protein kinase receptor. (2345 aa)    
Predicted Functional Partners:
EML4
Echinoderm microtubule-associated protein-like 4 isoform X1.
   
 0.720
KRAS
GTPase KRas isoform X3.
   
 0.668
PTN
Pleiotrophin isoform X1.
    
 0.650
PIK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.646
GAB1
GRB2-associated-binding protein 1 isoform X1.
    
 0.646
GRB2
Growth factor receptor-bound protein 2.
    
 0.637
LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3 isoform X1.
    
 0.634
MDK
Midkine.
    
 0.611
TNS3
Tensin-3 isoform X2.
    
 0.596
TNS1
Tensin-1 isoform X8.
    
 0.596
Your Current Organism:
Ursus arctos
NCBI taxonomy Id: 116960
Other names: U. arctos horribilis, Ursus arctos horribilis
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.