TSPAN12 protein (Ursus arctos) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

TSPAN12

Tetraspanin. (305 aa)

Predicted Functional Partners:

FZD4

0.780

RECK

0.767

NDP

0.762

ZNF408

0.708

LRP5

0.706

TSPAN17

0.688

TSPAN32

0.595

LGR4

0.594

ADGRA2

0.593

FAM49A

0.593

Your Current Organism:

Ursus arctos

NCBI taxonomy Id: 116960
Other names: U. arctos horribilis, Ursus arctos horribilis

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADGRA2	FZD4	A0A3Q7WGJ4	A0A3Q7Y7B6	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.478
ADGRA2	RECK	A0A3Q7WGJ4	A0A3Q7VLY3	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Reversion-inducing cysteine-rich protein with Kazal motifs isoform X1.	0.502
ADGRA2	TSPAN12	A0A3Q7WGJ4	A0A3Q7WL72	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	Tetraspanin.	0.593
FAM49A	TSPAN12	A0A3Q7Y8E8	A0A3Q7WL72	Protein FAM49A.	Tetraspanin.	0.593
FZD4	ADGRA2	A0A3Q7Y7B6	A0A3Q7WGJ4	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family.	0.478
FZD4	LGR4	A0A3Q7Y7B6	A0A3Q7WSF5	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	0.594
FZD4	LRP5	A0A3Q7Y7B6	A0A3Q7UF26	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.975
FZD4	NDP	A0A3Q7Y7B6	A0A3Q7XZK6	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Norrin.	0.965
FZD4	RECK	A0A3Q7Y7B6	A0A3Q7VLY3	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Reversion-inducing cysteine-rich protein with Kazal motifs isoform X1.	0.508
FZD4	TSPAN12	A0A3Q7Y7B6	A0A3Q7WL72	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Tetraspanin.	0.780
FZD4	ZNF408	A0A3Q7Y7B6	A0A3Q7XMB1	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	Zinc finger protein 408.	0.522
LGR4	FZD4	A0A3Q7WSF5	A0A3Q7Y7B6	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.594
LGR4	LRP5	A0A3Q7WSF5	A0A3Q7UF26	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	0.607
LGR4	NDP	A0A3Q7WSF5	A0A3Q7XZK6	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Norrin.	0.634
LGR4	TSPAN12	A0A3Q7WSF5	A0A3Q7WL72	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Tetraspanin.	0.594
LGR4	ZNF408	A0A3Q7WSF5	A0A3Q7XMB1	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	Zinc finger protein 408.	0.614
LRP5	FZD4	A0A3Q7UF26	A0A3Q7Y7B6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Frizzled-4 isoform X2; Belongs to the G-protein coupled receptor Fz/Smo family.	0.975
LRP5	LGR4	A0A3Q7UF26	A0A3Q7WSF5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Leucine-rich repeat-containing G-protein coupled receptor 4 isoform X1.	0.607
LRP5	NDP	A0A3Q7UF26	A0A3Q7XZK6	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Norrin.	0.715
LRP5	TSPAN12	A0A3Q7UF26	A0A3Q7WL72	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family.	Tetraspanin.	0.706