node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDC6 | MCM2 | A0A3Q7WUE0 | A0A3Q7WSY0 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC6 | MCM4 | A0A3Q7WUE0 | A0A3Q7XCX5 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC6 | MCM5 | A0A3Q7WUE0 | A0A3Q7VT75 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA helicase; Belongs to the MCM family. | 0.998 |
CDC6 | MCM7 | A0A3Q7WUE0 | A0A3Q7Y4Q8 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.998 |
CDC6 | ORC1 | A0A3Q7WUE0 | A0A3Q7WTV7 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.999 |
CDC6 | ORC2 | A0A3Q7WUE0 | A0A3Q7WCD2 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 2. | 0.999 |
CDC6 | ORC3 | A0A3Q7WUE0 | A0A3Q7XWI0 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 3 isoform X1. | 0.999 |
CDC6 | ORC4 | A0A3Q7WUE0 | A0A3Q7WE47 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.999 |
CDC6 | ORC5 | A0A3Q7WUE0 | A0A3Q7XB41 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 5 isoform X1. | 0.999 |
CDC6 | ORC6 | A0A3Q7WUE0 | A0A3Q7VN86 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | Origin recognition complex subunit 6 isoform X1. | 0.999 |
MCM2 | CDC6 | A0A3Q7WSY0 | A0A3Q7WUE0 | DNA helicase; Belongs to the MCM family. | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. | 0.998 |
MCM2 | MCM4 | A0A3Q7WSY0 | A0A3Q7XCX5 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM2 | MCM5 | A0A3Q7WSY0 | A0A3Q7VT75 | DNA helicase; Belongs to the MCM family. | DNA helicase; Belongs to the MCM family. | 0.999 |
MCM2 | MCM7 | A0A3Q7WSY0 | A0A3Q7Y4Q8 | DNA helicase; Belongs to the MCM family. | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.999 |
MCM2 | ORC1 | A0A3Q7WSY0 | A0A3Q7WTV7 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. | 0.996 |
MCM2 | ORC2 | A0A3Q7WSY0 | A0A3Q7WCD2 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 2. | 0.997 |
MCM2 | ORC3 | A0A3Q7WSY0 | A0A3Q7XWI0 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 3 isoform X1. | 0.994 |
MCM2 | ORC4 | A0A3Q7WSY0 | A0A3Q7WE47 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. | 0.996 |
MCM2 | ORC5 | A0A3Q7WSY0 | A0A3Q7XB41 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 5 isoform X1. | 0.996 |
MCM2 | ORC6 | A0A3Q7WSY0 | A0A3Q7VN86 | DNA helicase; Belongs to the MCM family. | Origin recognition complex subunit 6 isoform X1. | 0.935 |