AFV89375.1 protein (Acidipropionibacterium acidipropionici)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFV89375.1

Hypothetical protein. (69 aa)

Predicted Functional Partners:

AFV89376.1

0.773

AFV89377.1

0.441

AFV89378.1

0.441

AFV89379.1

0.441

AFV89380.1

0.441

AFV89381.1

0.441

AFV89382.1

0.441

AFV89383.1

0.441

AFV89384.1

0.441

AFV89385.1

0.441

Your Current Organism:

Acidipropionibacterium acidipropionici

NCBI taxonomy Id: 1171373
Other names: A. acidipropionici ATCC 4875, Acidipropionibacterium acidipropionici ATCC 4875, Acidipropionibacterium acidipropionici DSM 20272, Acidipropionibacterium acidipropionici JCM 6432, Propionibacterium acidipropionici ATCC 4875, Propionibacterium acidipropionici DSM 20272, Propionibacterium acidipropionici JCM 6432

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFV89375.1	AFV89376.1	PACID_15620	PACID_15630	Hypothetical protein.	Hypothetical protein.	0.773
AFV89375.1	AFV89377.1	PACID_15620	PACID_15640	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89378.1	PACID_15620	PACID_15650	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89379.1	PACID_15620	PACID_15660	Hypothetical protein.	Endodeoxyribonuclease RusA.	0.441
AFV89375.1	AFV89380.1	PACID_15620	PACID_15670	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89381.1	PACID_15620	PACID_15680	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89382.1	PACID_15620	PACID_15690	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89383.1	PACID_15620	PACID_15700	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89384.1	PACID_15620	PACID_15710	Hypothetical protein.	Hypothetical protein.	0.441
AFV89375.1	AFV89385.1	PACID_15620	PACID_15720	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89375.1	PACID_15630	PACID_15620	Hypothetical protein.	Hypothetical protein.	0.773
AFV89376.1	AFV89377.1	PACID_15630	PACID_15640	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89378.1	PACID_15630	PACID_15650	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89379.1	PACID_15630	PACID_15660	Hypothetical protein.	Endodeoxyribonuclease RusA.	0.441
AFV89376.1	AFV89380.1	PACID_15630	PACID_15670	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89381.1	PACID_15630	PACID_15680	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89382.1	PACID_15630	PACID_15690	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89383.1	PACID_15630	PACID_15700	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89384.1	PACID_15630	PACID_15710	Hypothetical protein.	Hypothetical protein.	0.441
AFV89376.1	AFV89385.1	PACID_15630	PACID_15720	Hypothetical protein.	Hypothetical protein.	0.441

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.909

expected number of edges:

23

PPI enrichment p-value:

0.00171

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

5 of 77

1.6

1.53

0.00030

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

4 of 12

2.31

2.73

4.99e-06

GO:0005847

mRNA cleavage and polyadenylation specificity factor complex

2 of 13

1.98

0.89

0.0206

GO:0005736

RNA polymerase I complex

2 of 13

1.98

0.89

0.0206

GO:0005666

RNA polymerase III complex

2 of 16

1.89

0.84

0.0245

GO:0140513

Nuclear protein-containing complex

6 of 537

0.84

0.58

0.0088

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1686

RNA polymerase II, core complex

4 of 12

2.31

2.65

7.49e-06

CL:1974

mRNA cleavage and polyadenylation specificity factor complex

2 of 10

2.09

0.86

0.0251

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

4 of 38

1.81

1.95

5.61e-05

map03015

mRNA surveillance pathway

3 of 81

1.36

0.77

0.0196

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

4 of 27

1.96

1.95

0.00010

MAP-72086

mRNA Capping

4 of 29

1.93

1.94

0.00010

MAP-113418

Formation of the Early Elongation Complex

4 of 29

1.93

1.94

0.00010

MAP-9018519

Estrogen-dependent gene expression

4 of 31

1.9

1.92

0.00010

MAP-75955

RNA Polymerase II Transcription Elongation

4 of 36

1.84

1.87

0.00010

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

4 of 73

1.53

1.08

0.0042

GOCC:0005736

RNA polymerase I complex

2 of 7

2.25

0.93

0.0190

GOCC:0005665

RNA polymerase II, core complex

2 of 8

2.19

0.93

0.0190

GOCC:0005847

mRNA cleavage and polyadenylation specificity factor complex

2 of 11

2.05

0.87

0.0234

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

3 of 55

1.53

0.82

0.0190

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

3 of 15

2.09

1.69

0.00052

KW-0349

Heme

2 of 23

1.73

0.68

0.0483

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036866

Ribonuclease Z/Hydroxyacylglutathione hydrolase-like

3 of 12

2.19

1.34

0.0030

IPR022712

Beta-Casp domain

2 of 2

2.79

1.0

0.0153

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01027

Beta-Casp domain

2 of 2

2.79

1.33

0.0038

SM01117

Cytochrome b5-like Heme/Steroid binding domain

2 of 16

1.89

0.7

0.0473

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