AFV90216.1 protein (Acidipropionibacterium acidipropionici)

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second shell of interactors

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

AFV90216.1

D-proline reductase, PrdB subunit. (269 aa)

Predicted Functional Partners:

AFV90214.1

0.998

AFV90218.1

0.986

AFV90213.1

0.889

AFV90217.1

0.784

AFV90215.1

0.717

AFV90969.1

0.495

AFV90212.1

0.428

Your Current Organism:

Acidipropionibacterium acidipropionici

NCBI taxonomy Id: 1171373
Other names: A. acidipropionici ATCC 4875, Acidipropionibacterium acidipropionici ATCC 4875, Acidipropionibacterium acidipropionici DSM 20272, Acidipropionibacterium acidipropionici JCM 6432, Propionibacterium acidipropionici ATCC 4875, Propionibacterium acidipropionici DSM 20272, Propionibacterium acidipropionici JCM 6432

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFV90212.1	AFV90213.1	PACID_24360	PACID_24370	Acetylornithine aminotransferase apoenzyme.	Respiratory-chain NADH dehydrogenase family protein.	0.687
AFV90212.1	AFV90214.1	PACID_24360	PACID_24380	Acetylornithine aminotransferase apoenzyme.	D-proline reductase (Dithiol).	0.541
AFV90212.1	AFV90215.1	PACID_24360	PACID_24390	Acetylornithine aminotransferase apoenzyme.	Hypothetical protein.	0.459
AFV90212.1	AFV90216.1	PACID_24360	PACID_24400	Acetylornithine aminotransferase apoenzyme.	D-proline reductase, PrdB subunit.	0.428
AFV90213.1	AFV90212.1	PACID_24370	PACID_24360	Respiratory-chain NADH dehydrogenase family protein.	Acetylornithine aminotransferase apoenzyme.	0.687
AFV90213.1	AFV90214.1	PACID_24370	PACID_24380	Respiratory-chain NADH dehydrogenase family protein.	D-proline reductase (Dithiol).	0.916
AFV90213.1	AFV90215.1	PACID_24370	PACID_24390	Respiratory-chain NADH dehydrogenase family protein.	Hypothetical protein.	0.549
AFV90213.1	AFV90216.1	PACID_24370	PACID_24400	Respiratory-chain NADH dehydrogenase family protein.	D-proline reductase, PrdB subunit.	0.889
AFV90213.1	AFV90217.1	PACID_24370	PACID_24410	Respiratory-chain NADH dehydrogenase family protein.	Putative transcriptional regulator.	0.638
AFV90213.1	AFV90218.1	PACID_24370	PACID_24420	Respiratory-chain NADH dehydrogenase family protein.	Proline racemase; Belongs to the proline racemase family.	0.758
AFV90214.1	AFV90212.1	PACID_24380	PACID_24360	D-proline reductase (Dithiol).	Acetylornithine aminotransferase apoenzyme.	0.541
AFV90214.1	AFV90213.1	PACID_24380	PACID_24370	D-proline reductase (Dithiol).	Respiratory-chain NADH dehydrogenase family protein.	0.916
AFV90214.1	AFV90215.1	PACID_24380	PACID_24390	D-proline reductase (Dithiol).	Hypothetical protein.	0.673
AFV90214.1	AFV90216.1	PACID_24380	PACID_24400	D-proline reductase (Dithiol).	D-proline reductase, PrdB subunit.	0.998
AFV90214.1	AFV90217.1	PACID_24380	PACID_24410	D-proline reductase (Dithiol).	Putative transcriptional regulator.	0.774
AFV90214.1	AFV90218.1	PACID_24380	PACID_24420	D-proline reductase (Dithiol).	Proline racemase; Belongs to the proline racemase family.	0.984
AFV90214.1	AFV90969.1	PACID_24380	PACID_32090	D-proline reductase (Dithiol).	Ornithine cyclodeaminase/mu-crystallin.	0.532
AFV90215.1	AFV90212.1	PACID_24390	PACID_24360	Hypothetical protein.	Acetylornithine aminotransferase apoenzyme.	0.459
AFV90215.1	AFV90213.1	PACID_24390	PACID_24370	Hypothetical protein.	Respiratory-chain NADH dehydrogenase family protein.	0.549
AFV90215.1	AFV90214.1	PACID_24390	PACID_24380	Hypothetical protein.	D-proline reductase (Dithiol).	0.673

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

49

average node degree:

8.91

avg. local clustering coefficient:

0.881

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000096

Sulfur amino acid metabolic process

3 of 22

1.91

1.04

0.0097

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008705

Methionine synthase activity

2 of 2

2.77

1.09

0.0106

GO:0031419

Cobalamin binding

2 of 3

2.6

1.08

0.0106

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9085

Mixed, incl. Transsulfuration, and Hint domain superfamily

3 of 6

2.47

1.83

0.00040

CL:540

Homocysteine-binding domain, and Transsulfuration

2 of 5

2.37

0.88

0.0242

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00270

Cysteine and methionine metabolism

3 of 37

1.68

1.13

0.0045

map00450

Selenocompound metabolism

2 of 21

1.75

0.71

0.0421

map04122

Sulfur relay system

2 of 26

1.66

0.7

0.0421

map00670

One carbon pool by folate

2 of 29

1.61

0.69

0.0421

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02574

Homocysteine S-methyltransferase

2 of 3

2.6

0.95

0.0191

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036873

Rhodanese-like domain superfamily

4 of 14

2.23

2.37

2.41e-05

IPR001763

Rhodanese-like domain

4 of 15

2.2

2.35

2.41e-05

IPR036589

Homocysteine-binding domain superfamily

2 of 3

2.6

0.99

0.0157

IPR003726

Homocysteine-binding domain

2 of 3

2.6

0.99

0.0157

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00450

Rhodanese Homology Domain

4 of 14

2.23

2.87

1.92e-06

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