AFZ15025.1 protein (Crinalium epipsammum) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

AFZ15025.1

Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein. (118 aa)

Predicted Functional Partners:

AFZ15026.1

0.439

AFZ15024.1

0.437

AFZ14337.1

0.434

AFZ15321.1

0.434

Your Current Organism:

Crinalium epipsammum

NCBI taxonomy Id: 1173022
Other names: C. epipsammum PCC 9333, Crinalium epipsammum PCC 9333, Crinalium sp. PCC 9333

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFZ14337.1	AFZ15025.1	Cri9333_3512	Cri9333_4236	KEGG: cyn:Cyan7425_1403 hypothetical protein; SPTR: Putative uncharacterized protein.	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	0.434
AFZ15024.1	AFZ15025.1	Cri9333_4235	Cri9333_4236	Transposase IS4 family protein; PFAM: Transposase DDE domain; InterPro IPR002559; KEGG: mar:MAE_35500 transposase; PFAM: Transposase, IS4-like; SPTR: Putative transposase.	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	0.437
AFZ15025.1	AFZ14337.1	Cri9333_4236	Cri9333_3512	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	KEGG: cyn:Cyan7425_1403 hypothetical protein; SPTR: Putative uncharacterized protein.	0.434
AFZ15025.1	AFZ15024.1	Cri9333_4236	Cri9333_4235	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	Transposase IS4 family protein; PFAM: Transposase DDE domain; InterPro IPR002559; KEGG: mar:MAE_35500 transposase; PFAM: Transposase, IS4-like; SPTR: Putative transposase.	0.437
AFZ15025.1	AFZ15026.1	Cri9333_4236	Cri9333_4237	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	PFAM: ACT domain; Small subunit of acetolactate synthase; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: npu:Npun_F1890 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit.	0.439
AFZ15025.1	AFZ15321.1	Cri9333_4236	Cri9333_4540	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	CsbD family protein; PFAM: CsbD-like; InterPro IPR008462; KEGG: ava:Ava_4678 CsbD-like; PFAM: CsbD-like; SPTR: CsbD-like protein; Belongs to the UPF0337 (CsbD) family.	0.434
AFZ15026.1	AFZ15025.1	Cri9333_4237	Cri9333_4236	PFAM: ACT domain; Small subunit of acetolactate synthase; COGs: COG0440 Acetolactate synthase small (regulatory) subunit; InterPro IPR004789:IPR002912:IPR019455; KEGG: npu:Npun_F1890 acetolactate synthase 3 regulatory subunit; PFAM: Acetolactate synthase, small subunit, C-terminal; Amino acid-binding ACT; PRIAM: Acetolactate synthase; SPTR: Acetolactate synthase 3 regulatory subunit; TIGRFAM: Acetolactate synthase, small subunit.	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	0.439
AFZ15321.1	AFZ15025.1	Cri9333_4540	Cri9333_4236	CsbD family protein; PFAM: CsbD-like; InterPro IPR008462; KEGG: ava:Ava_4678 CsbD-like; PFAM: CsbD-like; SPTR: CsbD-like protein; Belongs to the UPF0337 (CsbD) family.	Hypothetical protein; PFAM: Putative phospholipid-binding domain; KEGG: ava:Ava_2036 hypothetical protein; SPTR: Putative uncharacterized protein.	0.434

Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.213

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

4 of 21

1.73

1.67

0.00022

GO:0006090

Pyruvate metabolic process

4 of 23

1.69

1.64

0.00022

GO:0006091

Generation of precursor metabolites and energy

8 of 137

1.22

1.47

3.30e-06

GO:0005975

Carbohydrate metabolic process

6 of 98

1.24

1.26

0.00012

GO:0006096

Glycolytic process

3 of 16

1.73

1.19

0.0036

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0046912

Acyltransferase activity, acyl groups converted into alkyl on transfer

2 of 2

2.45

0.99

0.0155

GO:0004611

Phosphoenolpyruvate carboxykinase activity

2 of 2

2.45

0.99

0.0155

GO:0046872

Metal ion binding

8 of 431

0.72

0.49

0.0108

GO:0043167

Ion binding

9 of 831

0.49

0.32

0.0305

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:36747056

(2023) Complex regulation in a Comamonas platform for diverse aromatic carbon metabolism.

3 of 9

1.98

1.53

0.00094

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1873

Mixed, incl. Carbon metabolism, and Branched-chain amino acid biosynthetic process

9 of 118

1.34

2.03

7.89e-09

CL:1877

Citrate cycle (TCA cycle), and 3Fe-4S

4 of 25

1.66

1.59

0.00026

CL:1876

Citrate cycle (TCA cycle), and Alanine, aspartate and glutamate metabolism

5 of 46

1.49

1.56

0.00011

CL:2062

Glycolysis

3 of 10

1.93

1.5

0.0010

CL:1874

Mixed, incl. Citrate cycle (TCA cycle), and Alpha-amino acid metabolic process

6 of 92

1.27

1.3

0.00011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00680

Methane metabolism

5 of 29

1.69

2.34

1.52e-06

map00010

Glycolysis / Gluconeogenesis

5 of 33

1.63

2.21

2.18e-06

map01200

Carbon metabolism

9 of 114

1.35

2.19

6.25e-10

map00620

Pyruvate metabolism

6 of 53

1.51

2.12

6.13e-07

map01120

Microbial metabolism in diverse environments

11 of 288

1.04

1.36

6.25e-10

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0324

Glycolysis

3 of 9

1.98

1.44

0.0015

KW-0670

Pyruvate

3 of 12

1.85

1.39

0.0015

KW-0816

Tricarboxylic acid cycle

3 of 13

1.82

1.38

0.0015

KW-0460

Magnesium

5 of 89

1.2

1.0

0.0015

KW-0418

Kinase

4 of 86

1.12

0.77

0.0080

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR015813

Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily

3 of 8

2.03

1.14

0.0065

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (10%) [HD]

Permalink

Network

Neighborhood

Experiments

Cooccurrence

Databases

Coexpression

Textmining

Fusion

© STRING Consortium 2024

Credits

Access

Info

About