A0A0J9X5B7 protein (Geotrichum candidum) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

A0A0J9X5B7

Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid. (170 aa)

Predicted Functional Partners:

A0A0J9X4E9

0.999

A0A0J9X7C3

0.999

A0A0J9X8M9

0.999

A0A0J9X990

0.999

A0A0J9XAL2

0.999

A0A0J9XCP5

0.999

A0A0J9XCV0

0.999

A0A0J9XDC3

0.999

A0A0J9XDH4

0.999

A0A0J9XF23

0.999

Your Current Organism:

Geotrichum candidum

NCBI taxonomy Id: 1173061
Other names: ATCC 22600 [[Endomyces geotrichum]], CBS 615.84 [[Galactomyces candidus]], CBS 772.71 [[Endomyces geotrichum]], Dipodascus geotrichum, Endomyces geotrichum, G. candidum, Galactomyces candidum, Galactomyces candidus, Galactomyces candidus de Hoog & M.T. Smith, 2004, Galactomyces geotrichum, Geotrichum sp. S9, JCM 6359 [[Endomyces geotrichum]], NRRL Y-17569 [[Endomyces geotrichum]], Oospora lactis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0J9X4E9	A0A0J9X5B7	Belongs to the bacterial ribosomal protein bL17 family.	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	0.999
A0A0J9X4E9	A0A0J9X7C3	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X4E9	A0A0J9X8M9	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X4E9	A0A0J9X990	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X4E9	A0A0J9XAL2	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X4E9	A0A0J9XCP5	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X4E9	A0A0J9XCV0	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X4E9	A0A0J9XDC3	Belongs to the bacterial ribosomal protein bL17 family.	Similar to Saccharomyces cerevisiae YOL127W RPL25 Ribosomal 60S subunit protein L25; Belongs to the universal ribosomal protein uL23 family.	0.999
A0A0J9X4E9	A0A0J9XDH4	Belongs to the bacterial ribosomal protein bL17 family.	Belongs to the universal ribosomal protein uS3 family.	0.999
A0A0J9X4E9	A0A0J9XF23	Belongs to the bacterial ribosomal protein bL17 family.	annotation not available	0.999
A0A0J9X5B7	A0A0J9X4E9	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	Belongs to the bacterial ribosomal protein bL17 family.	0.999
A0A0J9X5B7	A0A0J9X7C3	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999
A0A0J9X5B7	A0A0J9X8M9	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999
A0A0J9X5B7	A0A0J9X990	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999
A0A0J9X5B7	A0A0J9XAL2	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999
A0A0J9X5B7	A0A0J9XCP5	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999
A0A0J9X5B7	A0A0J9XCV0	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999
A0A0J9X5B7	A0A0J9XDC3	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	Similar to Saccharomyces cerevisiae YOL127W RPL25 Ribosomal 60S subunit protein L25; Belongs to the universal ribosomal protein uL23 family.	0.999
A0A0J9X5B7	A0A0J9XDH4	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	Belongs to the universal ribosomal protein uS3 family.	0.999
A0A0J9X5B7	A0A0J9XF23	Similar to Saccharomyces cerevisiae YGL068W MNP1 Protein associated with the mitochondrial nucleoid.	annotation not available	0.999

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.922

expected number of edges:

10

PPI enrichment p-value:

1.04e-13

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006644

Phospholipid metabolic process

6 of 125

1.74

2.42

1.48e-06

GO:0008654

Phospholipid biosynthetic process

5 of 95

1.78

2.21

8.94e-06

GO:0006650

Glycerophospholipid metabolic process

5 of 97

1.77

2.2

8.94e-06

GO:0006629

Lipid metabolic process

7 of 291

1.44

1.91

1.74e-06

GO:0046474

Glycerophospholipid biosynthetic process

4 of 76

1.78

1.79

0.00013

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016780

Phosphotransferase activity, for other substituted phosphate groups

2 of 11

2.32

0.9

0.0223

GO:0042578

Phosphoric ester hydrolase activity

4 of 174

1.42

0.89

0.0103

GO:0003824

Catalytic activity

10 of 3163

0.56

0.4

0.0103

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15229

Inositol phosphate metabolism

3 of 12

2.46

1.84

0.00038

CL:9328

Mixed, incl. Glycerophospholipid catabolic process, and Cell cycle G1/S phase transition

3 of 13

2.42

1.83

0.00038

CL:13210

Phospholipid metabolism, and Phosphatidylserine decarboxylase

2 of 6

2.58

1.31

0.0041

CL:9330

Mixed, incl. Cell cycle G1/S phase transition, and SPX domain

2 of 7

2.52

1.27

0.0047

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00564

Glycerophospholipid metabolism

5 of 76

1.88

2.74

5.88e-07

map00562

Inositol phosphate metabolism

3 of 43

1.9

1.62

0.00050

map00030

Pentose phosphate pathway

2 of 21

2.04

1.16

0.0060

map04070

Phosphatidylinositol signaling system

2 of 48

1.68

0.82

0.0228

map01100

Metabolic pathways

8 of 1691

0.74

0.61

0.00054

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-1855183

Synthesis of IP2, IP, and Ins in the cytosol

2 of 5

2.66

1.12

0.0093

MAP-71336

Pentose phosphate pathway

2 of 14

2.22

0.87

0.0242

MAP-1483249

Inositol phosphate metabolism

2 of 16

2.16

0.87

0.0242

MAP-71387

Metabolism of carbohydrates

3 of 137

1.4

0.68

0.0362

MAP-1430728

Metabolism

7 of 1121

0.86

0.59

0.0093

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0460

Magnesium

3 of 46

1.88

1.36

0.0019

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00459

Inositol monophosphatase family

2 of 2

3.06

1.34

0.0038

PF01066

CDP-alcohol phosphatidyltransferase

2 of 5

2.66

1.2

0.0066

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR020583

Inositol monophosphatase, metal-binding site

2 of 2

3.06

1.08

0.0112

IPR020550

Inositol monophosphatase, conserved site

2 of 2

3.06

1.08

0.0112

IPR000760

Inositol monophosphatase-like

2 of 2

3.06

1.08

0.0112

IPR043130

CDP-alcohol phosphatidyltransferase, transmembrane domain

2 of 5

2.66

1.07

0.0112

IPR000462

CDP-alcohol phosphatidyltransferase

2 of 5

2.66

1.07

0.0112

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