A0A0J9XBN6 protein (Geotrichum candidum) - STRING interaction network

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

A0A0J9XBN6

Similar to Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity. (759 aa)

Predicted Functional Partners:

A0A0J9X7M8

0.989

A0A0J9X8P8

0.807

A0A0J9XDH4

0.690

A0A0J9YHB7

0.688

A0A0J9XDC3

0.686

A0A0J9XCP5

0.680

A0A0J9XCV0

0.675

A0A0J9XJN4

0.675

A0A0J9YHM2

0.675

A0A0J9X7C3

0.674

Your Current Organism:

Geotrichum candidum

NCBI taxonomy Id: 1173061
Other names: ATCC 22600 [[Endomyces geotrichum]], CBS 615.84 [[Galactomyces candidus]], CBS 772.71 [[Endomyces geotrichum]], Dipodascus geotrichum, Endomyces geotrichum, G. candidum, Galactomyces candidum, Galactomyces candidus, Galactomyces candidus de Hoog & M.T. Smith, 2004, Galactomyces geotrichum, Geotrichum sp. S9, JCM 6359 [[Endomyces geotrichum]], NRRL Y-17569 [[Endomyces geotrichum]], Oospora lactis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0J9X7C3	A0A0J9XBN6	annotation not available	Similar to Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity.	0.674
A0A0J9X7C3	A0A0J9XCP5	annotation not available	annotation not available	0.999
A0A0J9X7C3	A0A0J9XCV0	annotation not available	annotation not available	0.999
A0A0J9X7C3	A0A0J9XDC3	annotation not available	Similar to Saccharomyces cerevisiae YOL127W RPL25 Ribosomal 60S subunit protein L25; Belongs to the universal ribosomal protein uL23 family.	0.999
A0A0J9X7C3	A0A0J9XDH4	annotation not available	Belongs to the universal ribosomal protein uS3 family.	0.999
A0A0J9X7C3	A0A0J9XJN4	annotation not available	annotation not available	0.674
A0A0J9X7C3	A0A0J9YHB7	annotation not available	annotation not available	0.999
A0A0J9X7C3	A0A0J9YHM2	annotation not available	annotation not available	0.674
A0A0J9X7M8	A0A0J9X8P8	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	annotation not available	0.783
A0A0J9X7M8	A0A0J9XBN6	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	Similar to Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity.	0.989
A0A0J9X7M8	A0A0J9XCV0	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	annotation not available	0.559
A0A0J9X7M8	A0A0J9XDC3	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	Similar to Saccharomyces cerevisiae YOL127W RPL25 Ribosomal 60S subunit protein L25; Belongs to the universal ribosomal protein uL23 family.	0.894
A0A0J9X7M8	A0A0J9XDH4	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	Belongs to the universal ribosomal protein uS3 family.	0.904
A0A0J9X7M8	A0A0J9XJN4	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	annotation not available	0.656
A0A0J9X7M8	A0A0J9YHB7	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	annotation not available	0.901
A0A0J9X7M8	A0A0J9YHM2	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	annotation not available	0.656
A0A0J9X8P8	A0A0J9X7M8	annotation not available	Similar to Saccharomyces cerevisiae YGL195W GCN1 Positive regulator of the Gcn2p kinase activity.	0.783
A0A0J9X8P8	A0A0J9XBN6	annotation not available	Similar to Saccharomyces cerevisiae YFR009W GCN20 Positive regulator of the Gcn2p kinase activity.	0.807
A0A0J9X8P8	A0A0J9XCV0	annotation not available	annotation not available	0.690
A0A0J9X8P8	A0A0J9XDC3	annotation not available	Similar to Saccharomyces cerevisiae YOL127W RPL25 Ribosomal 60S subunit protein L25; Belongs to the universal ribosomal protein uL23 family.	0.950

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016192

Vesicle-mediated transport

10 of 352

1.5

2.83

1.74e-11

GO:0006888

Endoplasmic reticulum to Golgi vesicle-mediated transport

4 of 74

1.78

1.74

0.00017

GO:0048205

COPI coating of Golgi vesicle

2 of 2

3.04

1.6

0.0013

GO:0006887

Exocytosis

3 of 38

1.94

1.45

0.0013

GO:0046907

Intracellular transport

7 of 494

1.19

1.31

2.31e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005096

GTPase activator activity

7 of 122

1.8

3.21

6.20e-09

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030126

COPI vesicle coat

2 of 9

2.39

0.81

0.0327

GO:0005794

Golgi apparatus

4 of 268

1.22

0.64

0.0327

GO:0031410

Cytoplasmic vesicle

4 of 278

1.2

0.63

0.0327

GO:0005737

Cytoplasm

10 of 4900

0.35

0.25

0.0461

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17015

Haemolysin-III related, and ArfGAP domain superfamily

4 of 17

2.41

2.83

3.91e-06

CL:17019

ArfGAP domain superfamily

3 of 6

2.74

2.6

1.60e-05

CL:5042

COPI vesicle coat, and ADP-ribosylation factor 1-5

3 of 12

2.44

2.28

5.03e-05

CL:4742

Vesicle-mediated transport, and RAB geranylgeranylation

6 of 171

1.59

2.07

3.91e-06

CL:4747

Exocytosis, and RAB geranylgeranylation

3 of 41

1.91

1.47

0.0011

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04144

Endocytosis

10 of 230

1.68

3.98

1.18e-14

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

4 of 65

1.83

1.69

0.00029

MAP-6807878

COPI-mediated anterograde transport

4 of 66

1.83

1.68

0.00029

MAP-8856688

Golgi-to-ER retrograde transport

4 of 80

1.74

1.63

0.00029

MAP-199977

ER to Golgi Anterograde Transport

4 of 118

1.57

1.38

0.00071

MAP-948021

Transport to the Golgi and subsequent modification

4 of 121

1.56

1.37

0.00071

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0863

Zinc-finger

7 of 466

1.22

1.41

9.42e-06

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038508

ArfGAP domain superfamily

7 of 10

2.89

7.64

2.87e-15

IPR037278

ARFGAP/RecO-like zinc finger

7 of 10

2.89

7.64

2.87e-15

IPR001164

Arf GTPase activating protein

7 of 10

2.89

7.64

2.87e-15

IPR005225

Small GTP-binding protein domain

3 of 76

1.64

0.72

0.0364

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00105

Putative GTP-ase activating proteins for the small GTPase, ARF

7 of 10

2.89

8.12

3.13e-16

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