A0A0J9XGB1 protein (Geotrichum candidum) - STRING interaction network

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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[Homology]

Score

A0A0J9XGB1

Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (331 aa)

Predicted Functional Partners:

A0A0J9XGF5

0.830

A0A0J9XC80

0.813

A0A0J9XJ79

0.712

A0A0J9XJD7

0.711

A0A0J9X5T4

0.692

A0A0J9X7X3

0.684

A0A0J9XJ88

0.678

A0A0J9X722

0.675

A0A0J9XCP7

0.675

A0A0J9YHP8

0.675

Your Current Organism:

Geotrichum candidum

NCBI taxonomy Id: 1173061
Other names: ATCC 22600 [[Endomyces geotrichum]], CBS 615.84 [[Galactomyces candidus]], CBS 772.71 [[Endomyces geotrichum]], Dipodascus geotrichum, Endomyces geotrichum, G. candidum, Galactomyces candidum, Galactomyces candidus, Galactomyces candidus de Hoog & M.T. Smith, 2004, Galactomyces geotrichum, Geotrichum sp. S9, JCM 6359 [[Endomyces geotrichum]], NRRL Y-17569 [[Endomyces geotrichum]], Oospora lactis

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A0J9X5T4	A0A0J9X722	Isocitrate lyase.	annotation not available	0.471
A0A0J9X5T4	A0A0J9X7X3	Isocitrate lyase.	DAO domain-containing protein.	0.813
A0A0J9X5T4	A0A0J9XCP7	Isocitrate lyase.	annotation not available	0.471
A0A0J9X5T4	A0A0J9XGB1	Isocitrate lyase.	Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.692
A0A0J9X5T4	A0A0J9XJ79	Isocitrate lyase.	Isocitrate lyase.	0.790
A0A0J9X5T4	A0A0J9XJ88	Isocitrate lyase.	DAO domain-containing protein.	0.826
A0A0J9X5T4	A0A0J9YHP8	Isocitrate lyase.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.471
A0A0J9X722	A0A0J9X5T4	annotation not available	Isocitrate lyase.	0.471
A0A0J9X722	A0A0J9XC80	annotation not available	Belongs to the universal ribosomal protein uL22 family.	0.780
A0A0J9X722	A0A0J9XGB1	annotation not available	Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.675
A0A0J9X722	A0A0J9XGF5	annotation not available	Tryptophan synthase.	0.621
A0A0J9X722	A0A0J9XJ79	annotation not available	Isocitrate lyase.	0.471
A0A0J9X7X3	A0A0J9X5T4	DAO domain-containing protein.	Isocitrate lyase.	0.813
A0A0J9X7X3	A0A0J9XGB1	DAO domain-containing protein.	Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.684
A0A0J9X7X3	A0A0J9XGF5	DAO domain-containing protein.	Tryptophan synthase.	0.815
A0A0J9X7X3	A0A0J9XJ79	DAO domain-containing protein.	Isocitrate lyase.	0.813
A0A0J9X7X3	A0A0J9XJ88	DAO domain-containing protein.	DAO domain-containing protein.	0.809
A0A0J9XC80	A0A0J9X722	Belongs to the universal ribosomal protein uL22 family.	annotation not available	0.780
A0A0J9XC80	A0A0J9XCP7	Belongs to the universal ribosomal protein uL22 family.	annotation not available	0.780
A0A0J9XC80	A0A0J9XGB1	Belongs to the universal ribosomal protein uL22 family.	Similar to Saccharomyces cerevisiae YNL274C GOR1 Glyoxylate reductase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.813

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Network Stats

number of nodes:

11

number of edges:

30

average node degree:

5.45

avg. local clustering coefficient:

0.719

expected number of edges:

16

PPI enrichment p-value:

0.00125

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006310

DNA recombination

5 of 80

1.51

1.58

0.00021

GO:0015074

DNA integration

3 of 23

1.83

1.18

0.0074

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000150

DNA strand exchange activity

4 of 13

2.2

2.78

9.14e-06

GO:0140097

Catalytic activity, acting on DNA

5 of 129

1.3

1.23

0.00058

GO:0003677

DNA binding

5 of 353

0.87

0.51

0.0357

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7142

DNA strand exchange activity

4 of 11

2.28

3.04

3.50e-06

CL:7422

Mixed, incl. NUDIX hydrolase, and Transposase activity

3 of 7

2.35

2.27

0.00012

CL:7083

Mixed, incl. DNA metabolic process, and Transmembrane

7 of 193

1.27

1.59

3.50e-06

CL:7144

Recombinase zinc beta ribbon domain

2 of 5

2.32

1.38

0.0048

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0018995

Host cellular component

4 of 18

2.06

2.62

1.16e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036162

Resolvase-like, N-terminal catalytic domain superfamily

4 of 13

2.2

2.61

2.02e-05

IPR006119

Resolvase, N-terminal catalytic domain

4 of 13

2.2

2.61

2.02e-05

IPR025827

Recombinase zinc beta ribbon domain

3 of 6

2.41

2.17

0.00020

IPR038109

DNA-binding recombinase domain superfamily

3 of 9

2.24

1.96

0.00039

IPR011109

DNA-binding recombinase domain

3 of 9

2.24

1.96

0.00039

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00857

Resolvase, N terminal domain

3 of 11

2.15

2.07

0.00021

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