Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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iscSCysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. (417 aa)    
Predicted Functional Partners:
GWL_24870
FeS cluster assembly scaffold protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
 
 0.999
GWL_24890
Transcription regulator protein.
 
 
 0.987
hscB
Co-chaperone protein; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family.
 
 0.985
GWL_24820
Ferredoxin [2Fe-2S]-type protein.
 
 0.981
GWL_24860
Hypothetical protein; Belongs to the HesB/IscA family.
 
 
 0.979
GWL_29730
Regulator of disulfide bond formation redox protein; Belongs to the sulfur carrier protein TusA family.
   
 0.979
GWL_43460
Dinucleotide-utilizing enzyme protein.
   
 0.955
cyaY
Iron transport frataxin protein; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis.
  
 0.953
hscA
Molecular chaperone protein; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
 
 0.927
GWL_32100
Thiosulfate sulfurtransferase.
  
 0.919
Your Current Organism:
Herbaspirillum sp. GW103
NCBI taxonomy Id: 1175306
Other names: H. sp. GW103
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