STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ecaIMModification methylase EcaI; This methylase recognizes the double-stranded sequence GGTNACC, causes specific methylation on A-5 on both strands and protects the DNA from cleavage by the EcaI endonuclease. adenosyl-L-homocysteine + DNA 6-methylaminopurine; sp|P14827|MTEC_ENTCL;evalue=9e-011; PctID=34.96; score=69.3. (641 aa)    
Predicted Functional Partners:
MCBB_0204
Type III restriction protein res subunit; tr|K2RE26|K2RE26_METFO;evalue=0.0; PctID=75.79; score=1524; {ECO:0000313|EMBL:EKF86599,1}.
 
     0.943
moaA-2
Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z). diphosphate. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate; Name=S-adenosyl-L-methionine; Xref=ChEBI:CHEBI:59789; Evidence=; Note=Binds 1 S-adenosyl-L-methionine per subunit.; sp|A6US67|MOAA_METVS;evalue=5e-007; PctID=30.51; score=55.1; { [...]
       0.773
MCBB_0202
Putative protein; tr|K2QFL5|K2QFL5_METFO;evalue=2e-044; PctID=62.96; score=184; {ECO:0000313|EMBL:EKF86841,1}.
       0.494
MCBB_0206
Putative 26S protease regulatory subunit homolog MTH_1011; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity); sp|O27092|PRS2_METTH;evalue=2e-129; PctID=63.27; score=462.
       0.464
hsdR
The EcoAI enzyme recognizes 5'-GAGN(7)GTCA-3'. Subunit R is required for both nuclease and ATPase activities, but not for modification. double-stranded fragments with terminal 5'-phosphates; ATP is simultaneously hydrolyzed. three polypeptides R, M and S. complex, multifunctional systems which require ATP,S-adenosyl methionine and magnesium as cofactors and, in addition to their endonucleolytic and methylase activities,are potent DNA-dependent ATPases; sp|Q07736|T1RA_ECOLX;evalue=9e-036; PctID=27.84; score=152.
     
 0.449
mjaIIIM
Modification methylase MjaIII; This methylase recognizes the double-stranded sequence GATC, causes specific methylation on A-2 on both strands, and protects the DNA from cleavage by the MjaIII endonuclease. adenosyl-L-homocysteine + DNA 6-methylaminopurine; sp|Q58015|MTM3_METJA;evalue=1e-079; PctID=49.83; score=296.
 
   
 0.422
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.