STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
MCBB_0206Putative 26S protease regulatory subunit homolog MTH_1011; The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex (By similarity); sp|O27092|PRS2_METTH;evalue=2e-129; PctID=63.27; score=462. (373 aa)    
Predicted Functional Partners:
rpl2
50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
  
   0.615
potA
Spermidine/putrescine import ATP-binding protein PotA; {ECO:0000255|HAMAP-Rule:MF_01726}; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system. + polyamine(In). (PotA),two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). Rule:MF_01726}; Peripheral membrane protein Spermidine/putrescine importer (TC 3.A.1.11.1) family. Rule:MF_01726}; sp|A0PY57|POTA_CLONN;evalue=4e-051; PctID=34.30; score=202.
  
     0.575
MCBB_2073
Putative protein MJ0414; sp|Q57857|Y414_METJA;evalue=6e-075; PctID=40.83; score=281.
  
     0.566
MCBB_1602
UPF0278 protein; RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. Belongs to the HARP family.
  
     0.546
moaA-2
Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z). diphosphate. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate; Name=S-adenosyl-L-methionine; Xref=ChEBI:CHEBI:59789; Evidence=; Note=Binds 1 S-adenosyl-L-methionine per subunit.; sp|A6US67|MOAA_METVS;evalue=5e-007; PctID=30.51; score=55.1; { [...]
 
     0.531
MCBB_1194
Putative ABC transporter ATP-binding protein MJ1662; sp|Q59056|Y1662_METJA;evalue=7e-145; PctID=46.37; score=514.
  
     0.497
fusA
Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.
  
 
 0.473
valS
Valine-tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
  
  
 0.466
ecaIM
Modification methylase EcaI; This methylase recognizes the double-stranded sequence GGTNACC, causes specific methylation on A-5 on both strands and protects the DNA from cleavage by the EcaI endonuclease. adenosyl-L-homocysteine + DNA 6-methylaminopurine; sp|P14827|MTEC_ENTCL;evalue=9e-011; PctID=34.96; score=69.3.
       0.464
MCBB_0204
Type III restriction protein res subunit; tr|K2RE26|K2RE26_METFO;evalue=0.0; PctID=75.79; score=1524; {ECO:0000313|EMBL:EKF86599,1}.
       0.464
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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