STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purOIMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. (211 aa)    
Predicted Functional Partners:
purP
5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.
 
  
 0.948
guaB-2
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
  
 0.927
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
     
 0.903
MCBB_0117
Putative sugar kinase MTH_1544; sp|O27587|Y1544_METTH;evalue=1e-107; PctID=61.18; score=389; Belongs to the carbohydrate kinase PfkB family.
    
  0.901
surE
5'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
     
  0.900
MCBB_0218
Biopolymer transport protein ExbD/TolR; tr|F6D1M7|F6D1M7_METPW;evalue=2e-035; PctID=78.00; score=154; {ECO:0000313|EMBL:AEG17255,1}.
       0.689
cofE
Coenzyme F420:L-glutamate ligase; Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8- didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420- 0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives.
       0.678
purD
Phosphoribosylamine-glycine ligase; sp|A5UMK4|PUR2_METS3;evalue=2e-162; PctID=63.36; score=572; {ECO:0000255|HAMAP-Rule:MF_00138}; Belongs to the GARS family.
  
  
 0.676
MCBB_0219
Putative biopolymer transport protein ExbB homolog; sp|O27101|Y1022_METTH;evalue=3e-102; PctID=67.78; score=371.
       0.656
purM
Phosphoribosylformylglycinamidine cyclo-ligase; sp|A5UM16|PUR5_METS3;evalue=4e-125; PctID=66.96; score=447; {ECO:0000255|HAMAP-Rule:MF_00741}.
     
 0.654
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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