node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCBB_0302 | dnaG | MCBB_0302 | MCBB_0347 | KH domain-containing protein MJ0443; sp|Q57885|Y443_METJA;evalue=1e-045; PctID=50.55; score=182. | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | 0.689 |
MCBB_0302 | rio1 | MCBB_0302 | MCBB_0303 | KH domain-containing protein MJ0443; sp|Q57885|Y443_METJA;evalue=1e-045; PctID=50.55; score=182. | RIO-type serine/threonine-protein kinase Rio1; sp|Q57886|RIO1_METJA;evalue=3e-049; PctID=45.04; score=195. | 0.895 |
MCBB_0302 | top6A | MCBB_0302 | MCBB_0300 | KH domain-containing protein MJ0443; sp|Q57885|Y443_METJA;evalue=1e-045; PctID=50.55; score=182. | Type 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.742 |
MCBB_0302 | top6B | MCBB_0302 | MCBB_0301 | KH domain-containing protein MJ0443; sp|Q57885|Y443_METJA;evalue=1e-045; PctID=50.55; score=182. | Type 2 DNA topoisomerase 6 subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.738 |
MCBB_0847 | rad50 | MCBB_0847 | MCBB_0559 | Metallophosphoesterase{ECO:0000313|EMBL:AEG1785 0,1}; tr|F6D1P7|F6D1P7_METPW;evalue=2e-098; PctID=75.77; score=365. | DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.973 |
MCBB_0847 | rad50-1 | MCBB_0847 | MCBB_0846 | Metallophosphoesterase{ECO:0000313|EMBL:AEG1785 0,1}; tr|F6D1P7|F6D1P7_METPW;evalue=2e-098; PctID=75.77; score=365. | Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per homodimer; hook,which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another [...] | 0.997 |
MCBB_0847 | radA | MCBB_0847 | MCBB_2240 | Metallophosphoesterase{ECO:0000313|EMBL:AEG1785 0,1}; tr|F6D1P7|F6D1P7_METPW;evalue=2e-098; PctID=75.77; score=365. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.843 |
MCBB_0847 | radB | MCBB_0847 | MCBB_1637 | Metallophosphoesterase{ECO:0000313|EMBL:AEG1785 0,1}; tr|F6D1P7|F6D1P7_METPW;evalue=2e-098; PctID=75.77; score=365. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.835 |
MCBB_0847 | top6A | MCBB_0847 | MCBB_0300 | Metallophosphoesterase{ECO:0000313|EMBL:AEG1785 0,1}; tr|F6D1P7|F6D1P7_METPW;evalue=2e-098; PctID=75.77; score=365. | Type 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.683 |
dnaG | MCBB_0302 | MCBB_0347 | MCBB_0302 | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | KH domain-containing protein MJ0443; sp|Q57885|Y443_METJA;evalue=1e-045; PctID=50.55; score=182. | 0.689 |
dnaG | radA | MCBB_0347 | MCBB_2240 | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.720 |
dnaG | top6A | MCBB_0347 | MCBB_0300 | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Type 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.671 |
dnaG | top6B | MCBB_0347 | MCBB_0301 | DNA primase DnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. | Type 2 DNA topoisomerase 6 subunit B; Relaxes both positive and negative superturns and exhibits a strong decatenase activity. | 0.794 |
mre11 | rad50 | MCBB_0558 | MCBB_0559 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | 0.998 |
mre11 | rad50-1 | MCBB_0558 | MCBB_0846 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | Involved in DNA double-strand break repair (DSBR). The Rad50/Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and/or repositioning DNA ends into the Mre11 active site (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per homodimer; hook,which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another [...] | 0.973 |
mre11 | radA | MCBB_0558 | MCBB_2240 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | DNA repair and recombination protein RadA; Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. | 0.946 |
mre11 | radB | MCBB_0558 | MCBB_1637 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | DNA repair and recombination protein RadB; Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange. | 0.835 |
mre11 | top6A | MCBB_0558 | MCBB_0300 | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | Type 2 DNA topoisomerase 6 subunit A; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. | 0.683 |
rad50 | MCBB_0847 | MCBB_0559 | MCBB_0847 | DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | Metallophosphoesterase{ECO:0000313|EMBL:AEG1785 0,1}; tr|F6D1P7|F6D1P7_METPW;evalue=2e-098; PctID=75.77; score=365. | 0.973 |
rad50 | mre11 | MCBB_0559 | MCBB_0558 | DNA double-strand break repair Rad50 ATPase; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex; Belongs to the SMC family. RAD50 subfamily. | DNA double-strand break repair protein Mre11; Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. Belongs to the MRE11/RAD32 family. | 0.998 |