STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
alaSAlanine-tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (901 aa)    
Predicted Functional Partners:
valS
Valine-tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.
 
  
 0.923
glyS
Glycine-tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). + glycyl-tRNA(Gly). family; sp|O27874|SYG_METTH;evalue=0.0; PctID=67.15; score=789; {ECO:0000255|HAMAP-Rule:MF_00253}.
  
 
 0.923
ileS
Isoleucine-tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 
 0.922
leuS
Leucine-tRNA ligase; sp|O27552|SYL_METTH;evalue=0.0; PctID=60.64; score=1246; {ECO:0000255|HAMAP-Rule:MF_00049}; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.911
RPAP3
RNA polymerase II-associated protein 3; May for an interface between the RNA polymerase II enzyme and chaperone/scaffolding protein. ProRule:PRU00339}; sp|Q5ZKQ3|RPAP3_CHICK;evalue=1e-016; PctID=27.19; score=87.8.
   
 0.877
MCBB_0736
TPR repeat-containing protein MJ1345; sp|Q58741|Y1345_METJA;evalue=5e-028; PctID=31.70; score=126.
   
 0.877
MCBB_0741
TPR repeat-containing protein MJ0940; sp|Q58350|Y940_METJA;evalue=3e-020; PctID=28.37; score=99.4.
   
 0.877
Ogt1
UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase 110 kDa subunit; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1,EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistanc [...]
   
 0.877
MCBB_1297
Abortive infection protein; tr|F6D735|F6D735_METPW;evalue=3e-133; PctID=54.15; score=481; {ECO:0000313|EMBL:AEG18402,1}.
   
 0.877
MCBB_1841
Abortive infection protein; tr|F6D735|F6D735_METPW;evalue=1e-056; PctID=41.67; score=226; {ECO:0000313|EMBL:AEG18402,1}.
   
 0.877
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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