STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
agl13Epimerase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier. present at 'Asn-532' of S-layer glycoprotein Csg. No effect on 'Asn-47' and 'Asn-117' glycosylation of S-layer glycoprotein Csg. family; sp|D4GU69|AGL13_HALVD;evalue=3e-034; PctID=44.67; score=144. (154 aa)    
Predicted Functional Partners:
agl14
Reductase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier. present at 'Asn-532' of S-layer glycoprotein Csg. No effect on 'Asn-47' and 'Asn-117' glycosylation of S-layer glycoprotein Csg. family. Sequence=ELY33652.1; Type=Erroneous initiation; Note=Translati [...]
 
 
 0.995
agl12
Low-salt glycan biosynthesis protein Agl12; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier. Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Note=Binds 1 NAD(+) per subunit; present at 'Asn-532' of S-layer glycoprotein Csg. No effect on 'Asn-47' and 'A [...]
 
 
 0.993
UXS1
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Name=NAD(+); Xref=ChEBI:CHEBI:57540; biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1; Single-pass type II membrane protein Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q8NBZ7-1; Name=2; IsoId=Q8NBZ7-2; Sequence=VSP_016757; Name=3; IsoId=Q8NBZ7-3; Sequence=VSP_016756; family. UDP-glucuronic acid decarboxylase subfamily; sp|Q5PQX0|UXS1_RAT,sp|Q5R885|UXS1_PONAB, sp|Q8NBZ7|UXS1_ [...]
    
  0.902
rmlC
dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.
     
  0.900
rfbE
Could be an O-antigen transporter. biosynthesis. pass membrane protein; sp|P37781|RFBE_SHIFL;evalue=8e-011; PctID=20.36; score=68.9.
 
  
 0.645
MCBB_1849
Putative protein; tr|A0A0E3QB63|A0A0E3QB63_9EURY;evalue=2e-122; PctID=47.26; score=446; {ECO:0000313|EMBL:AKB46569,1}.
 
  
 0.644
aglR
Putative flippase AglR; Involved in the assembly of a N-linked pentasaccharide that decorates the S-layer glycoprotein and flagellins. Probably mediates or contributes to the translocation of the dolichol-phosphate-mannose across the membrane. membrane protein tetrasaccharide-and mannose-linked dolichol phosphate. The final mannose residue of the N-linked glycan decorating the S-layer glycoprotein is not added; sp|D4GYG8|AGLR_HALVD;evalue=1e-011; PctID=24.42; score=71.6.
 
  
 0.642
MCBB_0062
Nucleotidyl transferase; tr|F6D7N2|F6D7N2_METPW;evalue=1e-180; PctID=90.75; score=639; {ECO:0000313|EMBL:AEG17111,1}.
  
  
 0.614
rmlA
Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. diphosphate + dTDP-alpha-D-glucose. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Note=Binds 1 Mg(2+) ion per subunit; thymidylyltransferase family; sp|P95778|RMLA_STRMU;evalue=2e-110; PctID=67.48; score=398.
  
  
 0.613
MCBB_0372
Bifunctional protein GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP-GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1-P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcNAc and pyrophosphate (By similarity). = diphosphate + UDP-N-acetyl-alpha-D-glucosamine. CoA + N-acetyl-alpha-D-glucosamine 1-phosphate. glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2. glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glu [...]
  
  
 0.595
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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