STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trmBL1HTH-type sugar sensing transcriptional regulator TrmBL1; Global transcriptional repressor of the maltodextrin transport gene cluster (mdxE operon) and most likely of all genes encoding glycolytic enzymes. Acts by binding to the conserved TGM (Thermococcales-Glycolytic-Motif) sequences in their promoter region. Can also interact with non-TGM sequences. different sugars to TrmBL1. Binding of maltose and maltotriose results in derepression of the target genes. However, high sugar concentration results in formation of octamers with high affinity for DNA, which may prevent transcription of [...] (265 aa)    
Predicted Functional Partners:
MCBB_1749
Putative protein; tr|A0A090I3K2|A0A090I3K2_METFO;evalue=2e-135; PctID=92.94; score=488; {ECO:0000313|EMBL:CEA13833,1}.
  
     0.602
comD
Sulfopyruvate decarboxylase subunit alpha; Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4. subunits beta; sp|Q6M060|COMD_METMP;evalue=3e-052; PctID=57.67; score=203; {ECO:0000250|UniProtKB:P58415}.
  
    0.525
comE
Sulfopyruvate decarboxylase subunit beta; Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Note=Binds 1 thiamine pyrophosphate per subunit; sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4. subunits beta; sp|O27275|COME_METTH;evalue=4e-048; PctID=50.84; score=190; {ECO:0000250|UniProtKB:P58416}.
  
    0.525
comA
Phosphosulfolactate synthase; Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL). phosphoenolpyruvate + hydrogen sulfite. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; pH dependence: Optimum pH is 8.5; sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4; sp|Q57703|PSLS_METJA;evalue=1e-078; PctID=56.08; score=293.
   
    0.513
ybhF3
Putative ABC transporter ATP-binding protein YbhF; sp|P0A9U1|YBHF_ECOLI, sp|P0A9U2|YBHF_SHIFL;evalue=5e-058; PctID=44.94; score=224.
     
 0.490
abcG20
ABC transporter G family member 20; sp|Q8T674|ABCGK_DICDI;evalue=4e-025; PctID=22.69; score=115.
       0.475
MCBB_1198
Transcriptional regulator, ArsR family; tr|F6D656|F6D656_METPW;evalue=1e-101; PctID=68.90; score=375; {ECO:0000313|EMBL:AEG18269,1}.
 
   
 0.445
cdc6-1
ORC1-type DNA replication protein 1; Involved in regulation of DNA replication.
 
     0.418
MCBB_1436
Putative protein; tr|F6D7Z2|F6D7Z2_METPW;evalue=0.0; PctID=70.05; score=860; {ECO:0000313|EMBL:AEG18515,1}.
  
     0.415
MCBB_0586
MurG-related protein; tr|F6D5K6|F6D5K6_METPW;evalue=6e-127; PctID=64.39; score=460; {ECO:0000313|EMBL:AEG17623,1}.
       0.403
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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