STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
wecB1UDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. acetyl-alpha-D-mannosamine. family; sp|Q58899|WECB_METJA;evalue=1e-100; PctID=49.32; score=367. (438 aa)    
Predicted Functional Partners:
pseB
UDP-N-acetylglucosamine 4,6-dehydratase (inverting); Catalyzes the first step in the biosynthesis of pseudaminic acid, a sialic-acid-like sugar that is used to modify flagellin. Has both C6 dehydratase and C5 epimerase activities that result in the production of both UDP-2-acetamido-2,6-dideoxy-beta-L-arabino-4-hexulose and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose. acetamido-2,6-dideoxy-beta-L-arabino-hex-4-ulose + H(2)O. Name=NADP(+); Xref=ChEBI:CHEBI:58349; Evidence=; sp|Q0P8W4|PSEB_CAMJE;evalue=6e-095; PctID=53.19; score=347.
  
 
 0.941
wecB3
UDP-N-acetylglucosamine 2-epimerase; Catalyzes the reversible epimerization at C-2 of UDP-N-acetylglucosamine (UDP-GlcNAc) to produce UDP-N-acetylmannosamine (UDP-ManNAc), the activated donor of ManNAc residues. acetyl-alpha-D-mannosamine. Kinetic parameters: KM=0.36 mM for UDP-GlcNAc; pH dependence: Active from pH 6 to 10; Temperature dependence: Optimum temperature is 50 degrees Celsius.; family; sp|Q6LZC4|WECB_METMP;evalue=1e-083; PctID=50.15; score=310.
  
  
 
0.904
mfnD
Tyramine-L-glutamate ligase; Catalyzes the formation of an amide bond between tyramine and the gamma carboxy group of L-glutamate. The enzyme also accepts phenylethylamine in vitro. + gamma-glutamyltyramine. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit; Kinetic parameters: KM=0.8 mM for tyramine; KM=2.3 mM for L-glutamate; KM=1.5 mM for ATP; Note=kcat is 4.8 sec(-1) toward tyramine. kcat is 5.8 sec(-1) toward L-glutamate. kcat is 5.9 sec(-1) toward ATP.; pH dependence: Optimum pH is [...]
       0.667
MCBB_0333
UDP-N-acetylglucosamine 3-dehydrogenase; {ECO:0000305}; Catalyzes the NAD(+)-dependent oxidation of UDP-GlcNAc. Highly specific for UDP-GlcNAc, does not catalyze the oxidation of the substrate analogs UDP-Glc,UDP-GalNAc, N-acetylglucosamine and glucosamine. UDP-2-acetamido-3-dehydro-2-deoxy-alpha-D-glucopyranose + NADH. the presence of 2 mM UDP, 2 mM UDP-Glc or 3 mM UDP-GalNAc. Activity is unaffected by metal ions. Kinetic parameters: KM=180 uM for UDP-GalNAc; KM=180 uM for NAD(+); Vmax=1.5 umol/min/mg enzyme toward UDP-GalNAc; Vmax=1.6 umol/min/mg enzyme toward NAD(+); Note=kcat is 0. [...]
  
  
 0.638
agl12
Low-salt glycan biosynthesis protein Agl12; Lyase involved in N-glycan biosynthetic pathway that takes place under low-salt conditions (1.75 M instead of 3.4 M). Participates in the formation of the tetrasaccharide present at 'Asn-532' of S-layer glycoprotein Csg, consisting of a sulfated hexose, 2 hexoses and rhamnose. Involved in the addition of final rhamnose (sugar 4) of the tetrasaccharide on the dolichol phosphate carrier. Name=NAD(+); Xref=ChEBI:CHEBI:57540; Evidence=; Note=Binds 1 NAD(+) per subunit; present at 'Asn-532' of S-layer glycoprotein Csg. No effect on 'Asn-47' and 'A [...]
  
  
 0.638
vioA
dTDP-4-amino-4,6-dideoxy-D-glucose transaminase; Catalyzes the conversion of dTDP-4-dehydro-6-deoxy-D-glucose (dTDP-D-Glc4O) to dTDP-4-amino-4,6-dideoxy-D-glucose (dTDP-D-Qui4N). L-glutamine can also be used as amino donor. oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; Kinetic parameters: KM=980 uM for dTDP-D-Glc4O; Temperature dependence: Optimum temperature is 37 degrees Celsius; biosynthesis; sp|Q6U1I3|VIOA_SHIDY;evalue=6e-079; PctID=44.20; score=295; Belongs to the DegT/DnrJ/EryC1 family.
  
  
 0.605
MCBB_1288
Putative protein MJ1066; sp|Q58466|Y1066_METJA;evalue=7e-084; PctID=42.63; score=311; Belongs to the DegT/DnrJ/EryC1 family.
  
  
 0.605
degT
Pleiotropic regulatory protein; This membrane protein may function as a sensor protein and may transfer the signal of environmental stimuli to the regulatory region of target genes to activate or repress transcription of the genes. membrane protein; sp|P15263|DEGT_GEOSE;evalue=8e-063; PctID=43.00; score=241; Belongs to the DegT/DnrJ/EryC1 family.
  
  
 0.605
MCBB_0699
Putative protein; tr|K6SZH2|K6SZH2_9EURY;evalue=4e-105; PctID=46.24; score=388; {ECO:0000313|EMBL:EKQ51908,1}.
       0.574
MCBB_0439
Putative phospho-N-acetylmuramoyl-pentapeptide-transferase; sp|O26830|MRAY_METTH;evalue=1e-092; PctID=55.05; score=340; {ECO:0000255|HAMAP-Rule:MF_00038}.
  
  
 0.549
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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