STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
cysK1O-acetylserine sulfhydrylase; {ECO:0000303|}; Catalyzes the conversion of O-acetylserine (OAS) to cysteine through the elimination of acetate and addition of hydrogen sulfide. cysteine + acetate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; peptide derived from the C-terminus of serine acetyltransferase (CysE). This suggests that CysK1 may associate with CysE in vivo to form a bi-enzyme complex, in which the OASS activity is down-regulated. cysteine from L-serine: step 2/2. synthase family; sp|P0A535|CYSK_MYCBO,sp|P9WP54|CYSK_MYCTO, sp|P9WP55|CYSK_MYCTU;evalue=3e-09 [...] (326 aa)    
Predicted Functional Partners:
cysE
Catalyzes the acetylation of serine by acetyl-CoA to produce O-acetylserine (OAS). serine. cysteine from L-serine: step 1/2; sp|Q06750|CYSE_BACSU;evalue=1e-060; PctID=57.49; score=233.
 
 0.999
metC
Cystathionine beta-lyase; The enzymatic degradation of amino acids in cheese is believed to generate aroma compounds and therefore to be essential for flavor development. Cystathionine beta-lyase (CBL) can convert cystathionine to homocysteine but is also able to catalyze an alpha, gamma elimination. With methionine as a substrate, it produces volatile sulfur compounds which are important for flavor formation in Gouda cheese. NH(3) + pyruvate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence=; novo pathway; L-homocysteine from L-cystathionine: step 1/1; sp|A2RM21|METC_LAC [...]
 
 
 0.957
cysS
Cysteine-tRNA ligase; sp|Q5JD45|SYC_THEKO;evalue=8e-128; PctID=51.07; score=457; {ECO:0000255|HAMAP-Rule:MF_00041}; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.944
MCBB_1468
Putative aspartate aminotransferase; sp|Q60317|AAT_METJA;evalue=8e-093; PctID=47.59; score=340.
  
 0.925
ahcY
Adenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family.
  
 0.918
MCBB_1067
MoaD family protein; tr|F6D3P5|F6D3P5_METPW;evalue=1e-032; PctID=74.73; score=144; {ECO:0000313|EMBL:AEG18039,1}.
  
 
 0.917
cysD
Transforms O-acetylhomoserine into homocysteine. methionine + acetate. Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; sp|P50125|CYSD_EMENI;evalue=4e-137; PctID=59.51; score=488.
 
 
 0.914
aspC
Aspartate aminotransferase; sp|O58489|AAT_PYRHO;evalue=7e-023; PctID=24.69; score=108.
     
  0.900
metE
Methionine synthase; Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. Can use methylcobalamin and methylcobinamide as methyl donors, but methylcobalamin is not considered to be the physiological substrate (By similarity). Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence=; Note=Binds 1 zinc ion per subunit; novo pathway; sp|O26869|METE_METTH;evalue=3e-050; PctID=51.05; score=199; {ECO:0000255|HAMAP-Rule:MF_00288}.
  
 
 0.894
coaBC
Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine (By similarity). pantotheine 4'-phosphate + CO(2). = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine. Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence=; Note=Binds 1 FMN per subunit; (R)-pantothenate: step 2/5. (R)-pantothenate: step 3/5. oligomeric flavin containing Cys decarboxylase) superfamily. synthetase family; sp|Q58323|COABC_METJA;evalue=1e-0 [...]
    
 0.854
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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