Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
co-expression
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gene co-occurrence
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argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (336 aa)    
Predicted Functional Partners:
argB
Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily.
 0.999
argD
Acetylornithine aminotransferase; sp|O27392|ARGD_METTH;evalue=2e-128; PctID=55.78; score=459; {ECO:0000255|HAMAP-Rule:MF_01107}; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.
 
 
 0.999
argJ
Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family.
 
  
 0.995
argH
Argininosuccinate lyase; sp|Q2NGN7|ARLY_METST;evalue=3e-174; PctID=63.01; score=612; {ECO:0000255|HAMAP-Rule:MF_00006}.
 
  
 0.968
argG
Argininosuccinate synthase; sp|O27322|ASSY_METTH;evalue=1e-170; PctID=72.77; score=599; {ECO:0000255|HAMAP-Rule:MF_00005}; Belongs to the argininosuccinate synthase family. Type 1 subfamily.
 
  
 0.968
argF
Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. + L-citrulline. arginine from L-ornithine and carbamoyl phosphate: step 1/3; sp|Q2NI83|OTC_METST;evalue=2e-104; PctID=61.20; score=379; {ECO:0000255|HAMAP-Rule:MF_01109}; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.
  
  
 0.952
fen
Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
     
 0.860
asd-2
Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family.
 
  
0.805
rfcL
Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily.
     
 0.797
gshAB
Glutathione biosynthesis bifunctional protein GshAB; Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine. phosphate + gamma-L-glutamyl-L-cysteine. ADP + phosphate + glutathione. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence=; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence=; Note=Binds 2 magnesium or manganese ions per subunit; from L-cysteine and L-glutamate: step 1/2. from L-cysteine and L-glutamate: step 2/2. cysteine ligase type 1 family. Type 2 subfamily. Rule:MF_00782}; sp|Q8XK30|GSHAB_CLOPE;evalue=7e-103; PctID=58.39; score=374; {ECO:0000255|HAM [...]
  
  
 0.724
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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