STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
frhG-2Coenzyme F420 hydrogenase, subunit gamma; tr|H8I849|H8I849_METCZ;evalue=2e-013; PctID=38.15; score=83.2; {ECO:0000313|EMBL:AFD00867,1}. (310 aa)    
Predicted Functional Partners:
frhA1
Coenzyme F420 hydrogenase subunit alpha; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. coenzyme F420. Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408; Note=There are 12-13 Fe atoms/(alpha(1)beta(1)gamma(1)) unit of the FRH; Name=FAD; Xref=ChEBI:CHEBI:57692; subunit family. Sequence=AAB85780.1; Type=Erroneous initiation; Evidence=; sp|P19496|FRHA_METTH;evalue=3e-018; PctID=32.43; score=94.0.
 
 
 0.986
vhcA
F420-non-reducing hydrogenase vhc subunit A; sp|Q00404|VHCA_METVO;evalue=2e-116; PctID=47.17; score=419; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.949
mvhA
F420-non-reducing hydrogenase subunit A; Part of a complex that provides reducing equivalents for heterodisulfide reductase. Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Evidence=; subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr). subunit family; sp|P60227|MVHA_METTM;evalue=0.0; PctID=81.36; score=791; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.948
frhA3
Coenzyme F420 hydrogenase subunit alpha; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. coenzyme F420. Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408; Note=There are 12-13 Fe atoms/(alpha(1)beta(1)gamma(1)) unit of the FRH; Name=FAD; Xref=ChEBI:CHEBI:57692; subunit family. Sequence=AAB85780.1; Type=Erroneous initiation; Evidence=; sp|P19496|FRHA_METTH;evalue=0.0; PctID=81.28; score=675.
 
 
 0.936
hdrA3
CoB-CoM heterodisulfide reductase iron-sulfur subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
 
 0.898
mvhD
F420-non-reducing hydrogenase iron-sulfur subunit D; Part of a complex that provides reducing equivalents for heterodisulfide reductase. MvhD may form the contact site to heterodisulfide reductase (By similarity). Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:49601; Evidence=; Note=Binds 1 [2Fe-2S] cluster; subunits; MvhA, MvhD and MvhG. It forms a complex with the heterodisulfide reductase (hdr) (By similarity); sp|Q50781|MVHD_METTH;evalue=3e-072; PctID=90.65; score=270.
 
 
 0.890
vhcD
F420-non-reducing hydrogenase vhc iron-sulfur subunit D; sp|Q00405|VHCD_METVO;evalue=7e-049; PctID=61.59; score=192.
 
 
 0.890
frhB3
Coenzyme F420 hydrogenase subunit beta; Reduces the physiological low-potential two-electron acceptor coenzyme F420, and the artificial one-electron acceptor methylviologen. coenzyme F420. Name=Ni(2+); Xref=ChEBI:CHEBI:49786; Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408; Note=There are 12-13 Fe atoms per alpha/beta/gamma unit of the FRH; Name=FAD; Xref=ChEBI:CHEBI:57692; sp|P19499|FRHB_METTH;evalue=5e-123; PctID=75.80; score=440.
 
 
 0.870
hdrC3
CoB-CoM heterodisulfide reductase iron-sulfur subunit C; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrC may carry electrons from hydrogenase to HdrA. N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L- threonine + dihydromethanophenazine. Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence=; Note=Binds 2 [4Fe-4S] clusters per subunit; heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. subunits; HdrA, HdrB and HdrC. It forms a [...]
  
 
 0.869
hdrA1
CoB-CoM heterodisulfide reductase 1 iron-sulfur subunit A; Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B).
 
 
 0.868
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
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