STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yrhO3Putative protein YrhO; sp|O05405|YRHO_BACSU;evalue=1e-007; PctID=32.97; score=57.0. (225 aa)    
Predicted Functional Partners:
iscU2
Iron-sulfur cluster assembly scaffold protein IscU 2; A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. Binds 1 2Fe-2S cluster per subunit in a crystal formed under reducing conditions; this subunit provides 3 ligands while IscS2 provides the other ligand. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters; sp|P0DMG1|ISCU1_ARCFU,sp|P0DMG2|ISCU2_ARCFU; evalue=1e-043; PctID=67.97; score=174.
   
 
 0.838
MCBB_1441
Small GTP-binding protein; tr|F6D7Z7|F6D7Z7_METPW;evalue=2e-079; PctID=77.72; score=301; {ECO:0000313|EMBL:AEG18520,1}.
 
 0.814
MCBB_1749
Putative protein; tr|A0A090I3K2|A0A090I3K2_METFO;evalue=2e-135; PctID=92.94; score=488; {ECO:0000313|EMBL:CEA13833,1}.
  
     0.647
tarI
Putative ribitol-5-phosphate cytidylyltransferase; Provides activated ribitol phosphate for teichoic acid synthesis. CDP-ribitol. acid biosynthesis; sp|Q8RKI9|TARI_BACPZ;evalue=1e-075; PctID=56.22; score=282.
  
  
 0.565
birA
Bifunctional ligase/repressor BirA; Acts both as a biotin-[acetyl-CoA-carboxylase] ligase and a repressor. ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]; sp|E0U174|BIRA_BACPZ;evalue=4e-055; PctID=39.74; score=215; {ECO:0000255|HAMAP-Rule:MF_00978}.
 
   
 0.555
comD
Sulfopyruvate decarboxylase subunit alpha; Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4. subunits beta; sp|Q6M060|COMD_METMP;evalue=3e-052; PctID=57.67; score=203; {ECO:0000250|UniProtKB:P58415}.
  
    0.525
comE
Sulfopyruvate decarboxylase subunit beta; Involved in the biosynthesis of the coenzyme M (2-mercaptoethanesulfonic acid). Catalyzes the decarboxylation of sulfopyruvate to sulfoacetaldehyde. Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence=; Note=Binds 1 thiamine pyrophosphate per subunit; sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 4/4. subunits beta; sp|O27275|COME_METTH;evalue=4e-048; PctID=50.84; score=190; {ECO:0000250|UniProtKB:P58416}.
  
    0.525
MCBB_1198
Transcriptional regulator, ArsR family; tr|F6D656|F6D656_METPW;evalue=1e-101; PctID=68.90; score=375; {ECO:0000313|EMBL:AEG18269,1}.
 
   
 0.515
comA
Phosphosulfolactate synthase; Catalyzes the addition of sulfite to phosphoenolpyruvate (PEP) to yield (2R)-phospho-3-sulfolactate (PSL). phosphoenolpyruvate + hydrogen sulfite. Name=Mg(2+); Xref=ChEBI:CHEBI:18420; pH dependence: Optimum pH is 8.5; sulfoacetaldehyde from phosphoenolpyruvate and sulfite: step 1/4; sp|Q57703|PSLS_METJA;evalue=1e-078; PctID=56.08; score=293.
   
    0.513
MCBB_0071
Putative GTP-binding protein MJ1332; sp|Q58728|Y1332_METJA;evalue=4e-117; PctID=52.66; score=421.
 
   
 0.503
Your Current Organism:
Methanobacterium congolense
NCBI taxonomy Id: 118062
Other names: DSM 7095, M. congolense, Methanobacterium congolense Cuzin et al. 2001, OCM 786, strain C
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.